STMN1
STMN1 (stathmin 1, also known as OP18, SMN, PR22, PP19, PP17, Lag and LAP18) is a ubiquitous cytosolic phosphoprotein that regulates the microtubule filament system. It destabilises microtubules by preventing their assembly and promoting their disassembly. Browse Assay Genie's current range of STMN1 research reagents below, or read on for the biology behind the target.
STMN1 is involved in regulating the microtubule (MT) filament system by destabilising microtubules. It prevents microtubule assembly and promotes disassembly, which places it at the centre of processes that depend on dynamic cytoskeletal remodelling. The NCBI Gene summary describes the encoded protein as a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay, integrating regulatory signals from the cellular environment.
Phosphorylation is central to how the protein is studied. UniProt notes that phosphorylation at Ser-16 may be required for axon formation during neurogenesis. The annotation also links the protein to the control of learned and innate fear. The STMN1 protein is classed in the stathmin family, and the gene is annotated as producing multiple transcript variants that encode different isoforms. Researchers working with an STMN1 antibody or STMN1 ELISA kit therefore often consider which form of the protein, including its phosphorylation state, is relevant to their question. Mouse and rat each carry an orthologous Stmn1 gene.
The STMN1 gene is listed by HGNC within the stathmins group and also among the microRNA protein coding host genes. Its approved name, stathmin 1, was previously written as stathmin 1/oncoprotein 18, and the symbol was formerly listed as chromosome 1 open reading frame 215 (C1orf215). Other recorded aliases include FLJ32206. The related family member STMN2 is a useful comparator in studies of stathmin biology.
STMN1 destabilises microtubules by preventing assembly and promoting disassembly, making it a key protein for studying cytoskeletal regulation.
Phosphorylation of STMN1 at Ser-16 may be required for axon formation during neurogenesis, linking it to neuronal development.
STMN1 is proposed to act as an intracellular relay that integrates regulatory signals from the cellular environment.
UniProt annotates STMN1 as involved in the control of learned and innate fear, supporting its use in behavioural neuroscience.
STMN1 regulates the microtubule filament system by destabilising microtubules. It prevents microtubule assembly and promotes disassembly. It is described as a ubiquitous cytosolic phosphoprotein that may act as an intracellular relay for regulatory signals, and it has been linked to axon formation and fear responses.
STMN1 stands for stathmin 1, formerly stathmin 1/oncoprotein 18. Aliases include SMN, OP18, PR22, PP19, PP17, Lag, LAP18 and FLJ32206. The symbol was also previously listed as C1orf215. UniProt uses the protein name Stathmin. Multiple transcript variants encode different isoforms.
Yes. Mouse and rat both carry an orthologous gene named Stmn1. The protein belongs to the stathmin family, which also includes STMN2. Check the datasheet of any product for its validated reactivity.
Other stathmin family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P16949; product specifications from Assay Genie datasheets.