TLN1
TLN1 (talin 1) is a high molecular weight cytoskeletal protein concentrated at cell-matrix and cell-cell contacts, where it links major cytoskeletal structures to the plasma membrane. It is also known as ILWEQ and TLN. Browse Assay Genie's current range of TLN1 research reagents below, or read on for the biology behind the target.
TLN1 is a high molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contact. It is involved in connecting the major cytoskeletal structures to the plasma membrane. The encoded protein plays a significant role in the assembly of actin filaments and in the spreading and migration of various cell types, including fibroblasts and osteoclasts.
TLN1 codistributes with integrins in the cell surface membrane, helping adherent cells attach to extracellular matrices and lymphocytes attach to other cells. The N-terminus contains elements that direct localisation to cell-extracellular matrix junctions, while the C-terminus carries binding sites for proteins including beta-1-integrin, actin and vinculin. Together with KANK1, TLN1 co-organises the assembly of cortical microtubule stabilizing complexes, which are positioned to control microtubule-actin crosstalk at the rims of focal adhesions.
UniProt records the protein in the ruffle membrane of cell projections, the cytoskeleton, the cell surface and focal adhesions. The human TLN1 gene belongs to the HGNC groups for FERM domain containing genes and microRNA protein coding host genes. The mouse ortholog is Tln1, and TLN2 is a related talin gene. Researchers studying cell adhesion, migration and cytoskeletal organisation often examine TLN1 protein expression and localisation.
TLN1 sits at cell-matrix and cell-cell contacts and co-distributes with integrins, making it a central protein for studying attachment to the extracellular matrix.
TLN1 contributes to the spreading and migration of cell types such as fibroblasts and osteoclasts, supporting work on motility mechanisms.
The protein participates in actin filament assembly and binds actin and vinculin through its C-terminus, linking cytoskeletal structures to the membrane.
With KANK1, TLN1 co-organises cortical microtubule stabilizing complexes at focal adhesion rims, relevant to studies of microtubule and actin coordination.
TLN1 is a cytoskeletal protein concentrated at cell-matrix and cell-cell contacts. It connects major cytoskeletal structures to the plasma membrane, contributes to actin filament assembly, and with KANK1 organises cortical microtubule stabilizing complexes at focal adhesion rims.
The HGNC full name is talin 1, and UniProt lists the protein as Talin-1. Aliases include ILWEQ and TLN. A related gene, TLN2, also exists. Check the datasheet of any product for its validated reactivity and the isoform or region it targets.
According to NCBI Gene, the C-terminus of TLN1 contains binding sites for beta-1-integrin, actin and vinculin, while the N-terminus directs localisation to cell-extracellular matrix junctions. UniProt also describes cooperation with KANK1 at focal adhesion rims. The mouse ortholog is Tln1.
Talin family members and other focal adhesion and cytoskeletal targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y490; product specifications from Assay Genie datasheets.