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OXER1
OXER1, the oxoeicosanoid receptor 1 (also known as GPR170, TG1019 and GPCR), is a G protein-coupled receptor that binds eicosanoids and polyunsaturated fatty acids. It belongs to the leukotriene receptor gene group and signals through G(i)/G(o) proteins. Browse Assay Genie's current range of OXER1 research reagents below, or read on for the biology behind the target.
OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids. Its reported ligands include 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. The receptor appears to couple to the G(i)/G(o) families of heteromeric G proteins. Consistent with this, the NCBI Gene summary describes it as involved in the adenylate cyclase-inhibiting G protein-coupled receptor signalling pathway.
The OXER1 gene encodes oxoeicosanoid receptor 1, a membrane protein that is predicted to be active at the plasma membrane. Functionally it enables G protein-coupled receptor activity and icosanoid binding activity. UniProt places it in the G protein-coupled receptor 1 family, and HGNC classifies it within the leukotriene receptors gene group.
The receptor has also been catalogued under the names GPR170, TG1019 and GPCR, so literature and databases may use any of these labels. Researchers studying lipid-mediator signalling, eicosanoid recognition and G(i)/G(o)-coupled receptor pharmacology use OXER1 as a model for how polyunsaturated fatty acid derivatives are sensed at the cell surface.
OXER1 acts as a receptor for eicosanoids such as 5-oxo-ETE and 5(S)-HPETE, making it relevant to studies of lipid-mediator recognition.
As a G protein-coupled receptor 1 family member, OXER1 is a target for work on ligand binding and receptor activation.
OXER1 appears to couple to G(i)/G(o) proteins, supporting research into adenylate cyclase-inhibiting signalling pathways.
OXER1 responds to polyunsaturated fatty acids including arachidonic acid, informing research on how cells detect fatty acid-derived signals.
OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids, including 5-oxo-ETE, 5(S)-HPETE and arachidonic acid. It seems to couple to G(i)/G(o) heteromeric G proteins and is involved in adenylate cyclase-inhibiting G protein-coupled receptor signalling.
OXER1 stands for oxoeicosanoid receptor 1. Aliases and previous symbols include GPR170, TG1019 and GPCR. HGNC lists it in the leukotriene receptors gene group, and UniProt assigns it to the G protein-coupled receptor 1 family.
OXER1 is a membrane protein. NCBI Gene predicts it to be active in the plasma membrane, which fits its role as a cell-surface G protein-coupled receptor for eicosanoids. Check the datasheet of any product for its validated reactivity.
Other eicosanoid and leukotriene receptors and G protein-coupled receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TDS5; product specifications from Assay Genie datasheets.
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