SH3BGRL3
SH3BGRL3 (SH3 domain binding glutamate rich protein like 3) is a small member of the SH3BGR family. It may modulate glutaredoxin activity and is implicated in cytoskeleton organisation. Browse Assay Genie's current range of SH3BGRL3 research reagents below, or read on for the biology behind the target.
SH3BGRL3 is annotated as a protein that could act as a modulator of glutaredoxin biological activity. It may also play a role in cytoskeleton organisation, and NCBI Gene describes it as involved in this process. The exact mechanism by which SH3BGRL3 influences glutaredoxin function or the cytoskeleton is not defined in the sources used here, so it is best regarded as a regulatory protein whose roles are still being characterised.
In terms of localisation, SH3BGRL3 is found in the cytoplasm, specifically the cytosol, and in the ruffle membrane, a cell projection associated with dynamic cytoskeletal remodelling. It is also reported in the nucleus. This distribution is consistent with a protein that operates in more than one cellular compartment. The SH3BGRL3 gene belongs to the SH3BGR family, and orthologues exist in mouse and rat, both named Sh3bgrl3, which allows the protein to be studied in common model organisms.
The HGNC-approved name is SH3 domain binding glutamate rich protein like 3. The previous name used the wording SH3 domain binding glutamic acid-rich protein like 3, and UniProt records the protein as SH3 domain-binding glutamic acid-rich-like protein 3. Researchers studying SH3BGRL3 often do so in the context of redox-related regulation and cytoskeletal organisation, using the SH3BGRL3 antibody, SH3BGRL3 ELISA kit or recombinant SH3BGRL3 protein to examine expression and localisation.
SH3BGRL3 is implicated in cytoskeleton organisation, making it a candidate for studies of cytoskeletal regulation.
SH3BGRL3 could act as a modulator of glutaredoxin biological activity, relevant to work on glutaredoxin-linked pathways.
The protein is located at the ruffle membrane, a cell projection, linking it to studies of dynamic membrane structures.
SH3BGRL3 is reported in the cytosol, ruffle membrane and nucleus, so it suits investigation of protein distribution between compartments.
SH3BGRL3 could act as a modulator of glutaredoxin biological activity and may play a role in cytoskeleton organisation. NCBI Gene also describes it as involved in cytoskeleton organisation. Detailed mechanisms are not defined in the sources used for this page.
No aliases or previous symbols are listed for SH3BGRL3. HGNC names it SH3 domain binding glutamate rich protein like 3, with a previous name using the wording glutamic acid-rich. UniProt calls it SH3 domain-binding glutamic acid-rich-like protein 3.
Yes. Mouse and rat both have an ortholog named Sh3bgrl3, so the protein can be studied in these common model organisms. Check the datasheet of any product for its validated reactivity.
Other SH3 domain-containing proteins, adaptor proteins and cytoskeleton-associated targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H299; product specifications from Assay Genie datasheets.