MYO10
MYO10 (myosin X, also known as unconventional myosin-X, KIAA0799 and MyoX) is an unconventional myosin that works as an actin-based molecular motor. It should not be confused with conventional non-muscle myosin-10 (MYH10), which is a separate gene product. Browse Assay Genie's current range of MYO10 research reagents below, or read on for the biology behind the target.
The MYO10 gene encodes a member of the myosin superfamily. The protein is an unconventional myosin: it contains the basic domains of conventional myosins and is distinguished from other class members by its tail domain. It functions as an actin-based molecular motor and plays a role in integrating the F-actin and microtubule cytoskeletons during meiosis. UniProt places it in the myosin family of the TRAFAC class myosin-kinesin ATPase superfamily.
UniProt records MYO10 in several cytoskeletal and cell-projection compartments: cytosol, lamellipodium, ruffle, cytoskeleton, cell cortex, and both the tip and the membrane of filopodia. HGNC classifies the gene within three groups: pleckstrin homology domain containing, myosin heavy chains class X, and FERM domain containing. The mouse and rat orthologs are both named Myo10, so work on the myosin X protein can be compared across these species.
The UniProt function annotation describes an isoform of MYO10 that acts as a dominant-negative regulator of isoform 1. It suppresses the filopodia-inducing and axon outgrowth-promoting activities of that isoform. In hippocampal neurons, the same annotation states that it increases VASP retention in spine heads, which induces spine formation and spine head expansion. Because the symbols look alike, take care to distinguish the MYO10 gene from MYH10, the conventional non-muscle myosin. The HGNC-approved name is myosin X, and KIAA0799 and MyoX are recorded aliases.
MYO10 localises to filopodium tips and membranes, and one isoform is annotated as controlling filopodia-inducing activity, making it relevant to studies of cell projections.
In hippocampal neurons, MYO10 is annotated as increasing VASP retention in spine heads, driving spine formation and spine head expansion.
An annotated MYO10 isoform suppresses the axon outgrowth-promoting activity of isoform 1, offering a route into studies of isoform-level control of neuronal growth.
MYO10 acts as an actin-based motor and contributes to integrating F-actin and microtubule cytoskeletons during meiosis.
MYO10 is an unconventional myosin that works as an actin-based molecular motor. It contributes to integrating the F-actin and microtubule cytoskeletons during meiosis. UniProt also describes roles in filopodia induction, axon outgrowth and spine formation in hippocampal neurons, depending on the isoform.
No. MYO10 encodes an unconventional myosin, whereas MYH10 encodes conventional non-muscle myosin-10. NCBI Gene specifically warns against confusing them. MYO10 is also known as myosin X, KIAA0799 and MyoX, so check the symbol and aliases when searching the literature.
Yes. Orthologs named Myo10 are recorded in both mouse and rat, which allows MYO10 biology to be studied in common rodent models. Check the datasheet of any product for its validated reactivity.
Other unconventional myosins, myosin heavy chain family members and related cytoskeletal targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HD67; product specifications from Assay Genie datasheets.