FZD6
FZD6 (frizzled class receptor 6, also known as Hfz6) is a seven-transmembrane receptor for Wnt proteins. It belongs to the Class F frizzled group of G protein-coupled receptors and helps regulate Wnt/beta-catenin signalling and planar cell polarity. Browse Assay Genie's current range of FZD6 research reagents below, or read on for the biology behind the target.
FZD6 is a receptor for Wnt proteins. Frizzled receptors as a group are mostly coupled to the canonical beta-catenin pathway, in which activation of disheveled proteins leads to inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second pathway involving PKC and calcium fluxes has been described for some family members, and both pathways appear to involve interactions with G proteins. For FZD6 specifically, the NCBI Gene summary describes a role as a negative regulator of the canonical Wnt/beta-catenin cascade, thereby restraining processes associated with oncogenic transformation, cell proliferation and inhibition of apoptosis.
FZD6 may be involved in transducing and transmitting polarity information between cells during tissue morphogenesis and in differentiated tissues. Together with FZD3, it contributes to neural tube closure and to establishing planar cell polarity (PCP), notably the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells in the inner ear. UniProt annotates the protein at the cell membrane, including the cell surface and apical cell membrane, as well as cytoplasmic vesicle and endoplasmic reticulum membranes.
The FZD6 gene encodes a protein with a signal peptide, an N-terminal extracellular cysteine-rich domain and seven transmembrane domains. Unlike other family members, it lacks a C-terminal PDZ domain-binding motif. Alternative splicing produces multiple transcript variants, some of which encode proteins without a predicted signal peptide. HGNC lists earlier names including frizzled (Drosophila) homolog 6 and frizzled family receptor 6, and the mouse ortholog is Fzd6. The protein belongs to the G protein-coupled receptor Fz/Smo family.
FZD6 is a Wnt receptor reported to act as a negative regulator of the canonical Wnt/beta-catenin cascade, making it relevant to pathway regulation studies.
FZD6 helps establish planar cell polarity, including the orientation of stereocilia bundles on inner ear sensory cells, alongside FZD3.
Together with FZD3, FZD6 is involved in neural tube closure, linking the receptor to studies of tissue morphogenesis.
By inhibiting canonical Wnt signalling, FZD6 is linked to processes such as oncogenic transformation, proliferation and resistance to apoptosis.
FZD6 is a cell-surface receptor for Wnt proteins. It is described as a negative regulator of canonical Wnt/beta-catenin signalling and, together with FZD3, contributes to neural tube closure and planar cell polarity, including stereocilia orientation in the inner ear.
FZD6 is also known as Hfz6 and Frizzled-6. HGNC lists previous names such as frizzled (Drosophila) homolog 6, frizzled 6, seven transmembrane spanning receptor, and frizzled family receptor 6. Alternative splicing yields several transcript variants.
FZD6 has the usual signal peptide, cysteine-rich extracellular domain and seven transmembrane domains, but lacks the C-terminal PDZ domain-binding motif found in other family members. Its mouse ortholog is Fzd6. Check the datasheet of any product for its validated reactivity.
Other frizzled receptors and Wnt pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60353; product specifications from Assay Genie datasheets.