CRLS1
CRLS1 (cardiolipin synthase 1, also known as CLS1, GCD10, dJ967N21.6 and C20orf155) is a mitochondrial enzyme that catalyses the final synthesis of cardiolipin, a phospholipid central to mitochondrial membranes. It belongs to the CDP-alcohol phosphatidyltransferase class-I family. Browse Assay Genie's current range of CRLS1 research reagents below, or read on for the biology behind the target.
CRLS1 catalyses the synthesis of cardiolipin (CL), also called diphosphatidylglycerol, by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). Cardiolipin is a key phospholipid in mitochondrial membranes. It plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions, which makes CRLS1 a point of interest for anyone studying mitochondrial membrane biology.
The human CRLS1 gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family. The enzyme is classified as EC 2.7.8.41 and is described by UniProt as a CMP-forming cardiolipin synthase. It is located in the mitochondrial inner membrane, the compartment where cardiolipin acts as a phospholipid component critical for mitochondrial function. Mouse and rat each have a Crls1 ortholog, so the enzyme can be examined in common model systems.
The gene has carried several designations, including the previous name chromosome 20 open reading frame 155 (C20orf155), and the aliases CLS1, GCD10 and dJ967N21.6. Researchers working with the CRLS1 gene or CRLS1 protein will encounter these names in older literature and databases. HGNC lists the approved name as cardiolipin synthase 1.
CRLS1 produces cardiolipin, a key phospholipid of mitochondrial membranes, so it is central to studies of mitochondrial membrane composition.
The enzyme transfers a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol, making it a model for CDP-alcohol phosphatidyltransferase chemistry.
Cardiolipin helps maintain the functional integrity and dynamics of mitochondria, linking CRLS1 activity to mitochondrial behaviour.
Cardiolipin supports mitochondria under both optimal and stress conditions, making CRLS1 relevant to research on mitochondrial adaptation.
CRLS1 catalyses the synthesis of cardiolipin by transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol. Cardiolipin is a key phospholipid in mitochondrial membranes and helps maintain mitochondrial integrity and dynamics under optimal and stress conditions.
CRLS1 is also known as CLS1, GCD10, dJ967N21.6 and C20orf155. The last reflects its previous name, chromosome 20 open reading frame 155. UniProt names the protein cardiolipin synthase (CMP-forming), and HGNC uses cardiolipin synthase 1.
Yes, orthologs named Crls1 exist in both mouse and rat. This allows the enzyme to be studied in rodent models. Check the datasheet of any product for its validated reactivity before choosing a species.
Other mitochondrial enzymes and phospholipid-metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UJA2; product specifications from Assay Genie datasheets.