CD99L2
CD99L2 (CD99 molecule like 2, also known as CD99B and MIC2L1) is a cell-surface member of the CD99 family. It acts as a homophilic adhesion molecule and contributes to a late step of leukocyte extravasation. Browse Assay Genie's current range of CD99L2 research reagents below, or read on for the biology behind the target.
CD99L2 plays a role in a late step of leukocyte extravasation, helping cells to overcome the endothelial basement membrane. It acts at the same site as PECAM1 but independently of it. The protein is described as a homophilic adhesion molecule, although these homophilic interactions may not be required for cell aggregation.
The CD99L2 gene encodes a cell-surface protein that is similar to CD99, and the protein belongs to the CD99 family. UniProt annotates its subcellular locations as the cell membrane, cell junction and secreted fractions. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation, and mouse and rat orthologs (Cd99l2) are recorded. Alternate splicing of the gene results in multiple transcript variants.
The protein is also known as CD99 antigen-like protein 2. Earlier names include MIC2 like 1, CD99 antigen-like 2 and CD99 molecule-like 2, and the symbols CD99B and MIC2L1 are still found in older literature. Researchers studying CD99L2 often do so in the context of leukocyte trafficking and endothelial transmigration, alongside other CD99 family members and PECAM1.
CD99L2 contributes to a late step of extravasation, helping leukocytes cross the endothelial basement membrane.
CD99L2 is a homophilic adhesion molecule, though these interactions may not be required for cell aggregation.
CD99L2 acts at the same site as PECAM1 but independently, making it useful for dissecting parallel transmigration mechanisms.
As a CD99-like cell-surface protein, CD99L2 allows comparison of function across the CD99 family and with mouse orthologs.
CD99L2 plays a role in a late step of leukocyte extravasation, helping cells to overcome the endothelial basement membrane. It acts at the same site as PECAM1 but independently of it. It is a homophilic adhesion molecule, although these interactions may not be required for cell aggregation.
CD99L2 is also called CD99B and MIC2L1. Its previous names include MIC2 like 1, CD99 antigen-like 2 and CD99 molecule-like 2. UniProt lists the protein as CD99 antigen-like protein 2. NCBI reports that alternate splicing gives multiple transcript variants.
Yes. Mouse and rat orthologs, both named Cd99l2, are recorded. NCBI notes that a similar mouse protein functions as an adhesion molecule during leukocyte extravasation. Check the datasheet of any product for its validated reactivity.
Other CD99 family members, leukocyte adhesion molecules and related CD markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TCZ2; product specifications from Assay Genie datasheets.