CADM4
CADM4 (cell adhesion molecule 4) is a nectin-family membrane protein that mediates calcium- and magnesium-independent cell-cell adhesion. It is also known as TSLL2, Necl-4, SynCAM4 and IGSF4C. Browse Assay Genie's current range of CADM4 research reagents below, or read on for the biology behind the target.
CADM4 is a cell adhesion molecule that shows cell-cell adhesion activity independent of calcium and magnesium. In its palmitoylated form, it is required for proper oligodendrocyte maturation and myelination in the central nervous system, where it associates with other cell adhesion molecules such as CADM2, CADM3 and MAG. UniProt also notes that it may have tumour-suppressor activity.
The CADM4 protein belongs to the nectin family and is assigned by HGNC to the V-set domain containing, C2-set domain containing and nectins and nectin-like molecules gene groups. UniProt places it in the cell membrane and the Golgi apparatus membrane. The gene was previously named immunoglobulin superfamily, member 4C, and it is also known as TSLL2, Necl-4 and SynCAM4. Orthologous genes are named Cadm4 in mouse and rat.
NCBI Gene summary annotations describe CADM4 as enabling vascular endothelial growth factor receptor 2 binding. It is involved in negative regulation of protein phosphorylation, regulation of Rac protein signal transduction and regulation of wound healing. It is located at the cell leading edge and in the cell-cell contact zone, consistent with a role in cell-cell contacts and the signalling associated with them.
CADM4 is required in its palmitoylated form for oligodendrocyte maturation and CNS myelination, working with CADM2, CADM3 and MAG.
CADM4 mediates calcium- and magnesium-independent cell-cell adhesion and localises to the cell-cell contact zone, making it relevant to nectin-like adhesion studies.
UniProt reports that CADM4 may have tumour-suppressor activity, which motivates investigation of its role in cancer biology.
CADM4 binds VEGFR2 and is linked to Rac signal transduction, protein phosphorylation and wound healing regulation.
CADM4 is a cell adhesion molecule with calcium- and magnesium-independent cell-cell adhesion activity. In its palmitoylated form it is required for oligodendrocyte maturation and CNS myelination, associating with CADM2, CADM3 and MAG. It may also have tumour-suppressor activity.
CADM4 is also called TSLL2, Necl-4, SynCAM4 and IGSF4C. The previous HGNC name was immunoglobulin superfamily, member 4C. The current name, cell adhesion molecule 4, reflects its membership of the CADM group of nectin-like molecules.
Yes. Mouse and rat both have an ortholog named Cadm4, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity.
Other CADM family adhesion molecules and nectin-like proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NFZ8; product specifications from Assay Genie datasheets.