SIRPB1
SIRPB1 (signal regulatory protein beta 1, also known as CD172b, SIRP-BETA-1 and SIRB1) is an immunoglobulin-like cell surface receptor of the SIRP family. It is linked to the regulation of receptor tyrosine kinase-coupled signalling and to activation of myeloid cells through TYROBP. Browse Assay Genie's current range of SIRPB1 research reagents below, or read on for the biology behind the target.
SIRPB1 is an immunoglobulin-like cell surface receptor. UniProt annotates it as involved in the negative regulation of receptor tyrosine kinase-coupled signalling processes, and it also participates in the recruitment of the tyrosine kinase SYK. When associated with TYROBP, it triggers activation of myeloid cells. NCBI Gene reports that the protein interacts with TYROBP, also called DAP12, an adaptor that bears immunoreceptor tyrosine-based activation motifs.
The SIRPB1 gene encodes a member of the signal-regulatory-protein (SIRP) family, which belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins, and the SIRPB1 protein is localised to the cell membrane. According to RefSeq, multiple transcript variants of the gene encode different isoforms. The protein is a single-pass receptor of the kind studied in myeloid cell signalling.
In HGNC, SIRPB1 is classified among CD molecules, V-set domain containing genes, C1-set domain containing genes and the signal regulatory proteins group. Its alternative names include CD172b, SIRP-BETA-1 and SIRB1. Researchers studying the SIRPB1 protein often examine it alongside other SIRP family receptors and the TYROBP adaptor to understand how activating and inhibitory signals are balanced at the cell surface.
SIRPB1 triggers activation of myeloid cells when associated with TYROBP, making it relevant to studies of myeloid receptor signalling.
SIRPB1 interacts with TYROBP/DAP12, an adaptor carrying immunoreceptor tyrosine-based activation motifs, so it is useful for studying ITAM-linked pathways.
SIRPB1 participates in the recruitment of the tyrosine kinase SYK, a step relevant to downstream signal transduction analysis.
As a SIRP family member, SIRPB1 helps researchers compare receptors involved in negative regulation of receptor tyrosine kinase-coupled signalling.
SIRPB1 is an immunoglobulin-like cell surface receptor. UniProt describes a role in negative regulation of receptor tyrosine kinase-coupled signalling and in recruiting the tyrosine kinase SYK. When associated with TYROBP, it triggers activation of myeloid cells.
SIRPB1 is also known as CD172b, SIRP-BETA-1 and SIRB1, and its previous name was signal-regulatory protein beta 1. RefSeq notes that multiple transcript variants of the SIRPB1 gene encode different isoforms.
The data supplied for SIRPB1 do not identify mouse or rat orthologues, so none is stated here. The protein belongs to the SIRP family within the immunoglobulin superfamily. Check the datasheet of any product for its validated reactivity.
Other SIRP family receptors, the TYROBP adaptor and SYK kinase, which are linked to SIRPB1 signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00241; product specifications from Assay Genie datasheets.