CEND1
CEND1 (cell cycle exit and neuronal differentiation 1) is a neuron-specific membrane protein involved in neuronal differentiation. It is also known as BM88 and FLJ90066, and belongs to the CEND1 family. Browse Assay Genie's current range of CEND1 research reagents below, or read on for the biology behind the target.
CEND1 is a neuron-specific protein that is involved in neuronal differentiation. UniProt annotates it as a membrane protein, and the name reflects its association with the transition from cell cycle exit to a differentiated neuronal state. The detailed molecular mechanism is not described in the sources used for this page.
Evidence for its role comes in part from work on the equivalent protein in pig, which enhances the differentiation of neuroblastoma cells in vitro and may contribute to neuronal differentiation in vivo. This makes CEND1 a useful subject for researchers studying how neurons leave the cell cycle and acquire a mature phenotype, and for those looking for markers of neuronal lineage commitment.
The human CEND1 gene is approved by HGNC under the name cell cycle exit and neuronal differentiation 1, and the protein is a member of the CEND1 family. The gene has also been referred to as BM88 and FLJ90066. Orthologues are annotated in mouse and rat, both named Cend1, which allows comparative work in common rodent models. Multiple pseudogenes have been reported for this gene, which is worth bearing in mind when designing nucleic acid based assays for the CEND1 gene.
CEND1 is involved in neuronal differentiation, making it a relevant target for studying how neural cells commit to and progress through a differentiated state.
The pig counterpart of CEND1 enhances neuroblastoma cell differentiation in vitro, supporting its use in studies of differentiation in neuroblastoma-derived cells.
As a neuron-specific protein, CEND1 can serve as a point of reference when examining neuronal identity and lineage-restricted expression.
Mouse and rat both carry a Cend1 orthologue, enabling cross-species investigation of the role of this protein in neuronal development.
CEND1 is a neuron-specific membrane protein involved in neuronal differentiation. The related pig protein enhances neuroblastoma cell differentiation in vitro and may act in neuronal differentiation in vivo. Its precise molecular mechanism is not detailed in the sources used here.
CEND1 stands for cell cycle exit and neuronal differentiation 1. Aliases include BM88 and FLJ90066. UniProt lists the protein as cell cycle exit and neuronal differentiation protein 1, a member of the CEND1 family.
Yes. Mouse and rat both have an orthologue named Cend1, and a similar protein has been studied in pig. Researchers should check the datasheet of any product for its validated reactivity. Multiple pseudogenes have also been reported for the human gene.
Other neuronal differentiation and neuron-specific markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N111; product specifications from Assay Genie datasheets.