RS1
RS1 (retinoschisin 1, also known as XLRS1 and RS) is an extracellular protein that is required for the normal structure and function of the retina. It is secreted by photoreceptors and bipolar cells and is linked to X-linked retinoschisis. Browse Assay Genie's current range of RS1 research reagents below, or read on for the biology behind the target.
RS1 encodes retinoschisin, an extracellular protein that plays a crucial role in the cellular organisation of the retina. The protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric complex. It binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides, which is consistent with its association with the cell membrane as well as its secreted form.
RS1 is thought to contribute to cell-cell adhesion in the retina. The proposed mechanism is homomeric interaction between octamers present on the surface of two neighbouring cells, so that the protein helps hold retinal cell layers together. UniProt describes RS1 as required for normal structure and function of the retina. The mouse ortholog is Rs1, which makes the mouse a natural system for studying the protein in vivo.
The gene is also called XLRS1 or RS, and its earlier HGNC name was retinoschisis (X-linked, juvenile) 1. These names reflect its disease association. Mutations in the RS1 gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males. The condition causes a splitting of the inner layers of the retina and severe loss of vision. Researchers studying the RS1 protein therefore work on retinal organisation, extracellular assembly and the mechanisms behind this disorder.
RS1 is secreted by photoreceptors and bipolar cells and is crucial for the cellular organisation of the retina.
Mutations in RS1 cause X-linked retinoschisis, an early-onset macular degeneration in males marked by severe vision loss.
RS1 octamers on neighbouring cells are proposed to interact homomerically, making it a model for adhesion in retinal tissue.
RS1 binds phosphatidylserine and phosphoinositides, providing a route to study how secreted proteins associate with cell membranes.
RS1 is an extracellular protein needed for the normal structure and function of the retina. It binds negatively charged membrane lipids such as phosphatidylserine and phosphoinositides, and may mediate cell-cell adhesion in the retina through interactions between octamers on neighbouring cells.
RS1 is the HGNC symbol for retinoschisin 1. Aliases and previous symbols include XLRS1 and RS, and the earlier gene name was retinoschisis (X-linked, juvenile) 1. UniProt lists the protein simply as retinoschisin.
Yes. Mutations in the RS1 gene are responsible for X-linked retinoschisis, an early-onset macular degeneration in males. The mouse ortholog is Rs1; check the datasheet of any product for its validated reactivity.
Other targets with similar-looking names and related research interest, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15537; product specifications from Assay Genie datasheets.