PLAGL1
PLAGL1 (PLAG1 like zinc finger 1, also known as ZAC and LOT1) is a nuclear C2H2-type zinc finger protein that acts as a transcriptional activator and a suppressor of cell growth. The gene is imprinted and is linked to both cancer and transient neonatal diabetes mellitus. Browse Assay Genie's current range of PLAGL1 research reagents below, or read on for the biology behind the target.
PLAGL1 acts as a transcriptional activator. UniProt annotates it as involved in the transcriptional regulation of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. According to the NCBI Gene summary, the encoded protein functions as a suppressor of cell growth, which fits with its role as a regulator of gene expression in the nucleus, where it is located.
The PLAGL1 gene encodes a C2H2 zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. HGNC places it in the C2H2-type zinc fingers gene group. Alternative splicing and the use of alternative promoters produce multiple transcript variants, which encode two different protein isoforms. The P1 downstream promoter is imprinted, with preferential expression from the paternal allele in many tissues. This makes the PLAGL1 gene a useful subject for studies of genomic imprinting.
PLAGL1 is often deleted, or methylated and silenced, in cancer cells, which is consistent with a growth-suppressive function. Overexpression during foetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). The protein is also known as ZAC and LOT1, and its previous HGNC name was pleiomorphic adenoma gene-like 1. These properties make PLAGL1 a target of interest for researchers working on growth control, epigenetic silencing and developmental disease.
PLAGL1 is often deleted or methylated and silenced in cancer cells, and it functions as a suppressor of cell growth.
The P1 downstream promoter of PLAGL1 is imprinted, with preferential expression from the paternal allele in many tissues.
Overexpression of PLAGL1 during foetal development is thought to be the causal factor for transient neonatal diabetes mellitus.
PLAGL1 is a nuclear transcriptional activator involved in regulating the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
PLAGL1 acts as a transcriptional activator in the nucleus. UniProt describes its involvement in regulating transcription of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide, and the NCBI Gene summary describes it as a suppressor of cell growth.
PLAGL1 is also known as ZAC and LOT1, and was previously named pleiomorphic adenoma gene-like 1. Alternative splicing and alternative promoters give multiple transcript variants, which encode two different protein isoforms, so check which isoform is relevant to your work.
Yes. The gene is often deleted or methylated and silenced in cancer cells. Overexpression during foetal development is thought to cause transient neonatal diabetes mellitus. Its P1 promoter is imprinted, with preferential paternal-allele expression in many tissues.
Other zinc finger transcription factors, PACAP signalling components and growth-regulatory proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UM63; product specifications from Assay Genie datasheets.