OCM
OCM (oncomodulin, also known as OCM1 and Oncomodulin-1) is a high-affinity calcium ion-binding protein of the parvalbumin family. It shows some calmodulin-like activity in enzyme activation and growth regulation, and it is classed as an oncodevelopmental protein. Browse Assay Genie's current range of OCM research reagents below, or read on for the biology behind the target.
OCM is a high-affinity calcium ion-binding protein. UniProt records that it binds two calcium ions and has some calmodulin-like activity with respect to enzyme activation and growth regulation. In this respect it resembles calmodulin, although it is a distinct, smaller protein and not a calmodulin paralogue in the strict sense. Researchers working on calcium-dependent regulation therefore often study oncomodulin alongside other EF-hand proteins.
The OCM gene encodes Oncomodulin-1, which belongs to the parvalbumin family. NCBI Gene places it in the wider superfamily of calmodulin proteins, also known as the EF-hand proteins, and HGNC lists it in the EF-hand domain containing gene group. Orthologues are recognised in mouse and rat, both named Ocm, which allows the protein to be examined in common rodent models. A subcellular location is not annotated in UniProt, so localisation should be established experimentally for the system under study.
Oncomodulin takes its name from its description as an oncodevelopmental protein. According to the RefSeq summary, it is found in early embryonic cells in the placenta and also in tumours. This pattern of appearance in both developing tissue and neoplastic tissue is the reason for the prefix onco- in the name. Studies of the OCM gene, the oncomodulin protein and any OCM antibody or OCM ELISA kit used to detect it are therefore relevant to calcium signalling, development and tumour biology. The symbol OCM1 appears as an alias in the nomenclature records.
OCM binds two calcium ions with high affinity, making it a useful model for EF-hand calcium-binding behaviour.
Oncomodulin shows some calmodulin-like activity in enzyme activation, which makes it relevant to calcium-dependent regulation.
UniProt links oncomodulin to calmodulin-like effects on growth regulation, supporting work on how calcium-binding proteins influence cell growth.
As an oncodevelopmental protein found in early placental embryonic cells and in tumours, OCM is studied in development and cancer.
OCM is a high-affinity calcium ion-binding protein that binds two calcium ions. UniProt reports that it has some calmodulin-like activity with respect to enzyme activation and growth regulation. It belongs to the parvalbumin family within the EF-hand protein superfamily.
The HGNC approved name is oncomodulin and the symbol is OCM. UniProt lists the protein as Oncomodulin-1, and OCM1 is recorded as an alias. No previous HGNC names are listed. The gene belongs to the EF-hand domain containing group.
Yes. Mouse and rat orthologues exist and both are named Ocm, so the protein can be studied in rodent systems. Oncomodulin is described as an oncodevelopmental protein found in early placental embryonic cells and in tumours. Check the datasheet of any product for its validated reactivity.
Other EF-hand calcium-binding proteins, parvalbumin family members and calmodulins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P0CE72; product specifications from Assay Genie datasheets.