KLF2
KLF2 (KLF transcription factor 2, also known as LKLF) is a nuclear zinc finger transcription factor of the Krueppel family. It binds the CACCC box in target gene promoters and activates their transcription. Browse Assay Genie's current range of KLF2 research reagents below, or read on for the biology behind the target.
KLF2 is a transcription factor that binds the CACCC box in the promoter of target genes, such as HBB (beta globin) and NOV, and activates their transcription. It may also contribute to transcriptional regulation by modulating the binding of the nuclear receptor RARA to RARE DNA elements. The protein is found in the nucleus, consistent with its role in controlling gene expression.
The KLF2 gene encodes a zinc finger protein that belongs to the Krueppel C2H2-type zinc-finger family and sits within the KLF transcription factor gene group. According to the NCBI Gene summary, the protein is expressed early in mammalian development and is found in many different cell types. Mouse and rat each carry a Klf2 ortholog.
KLF2 was previously named Kruppel-like factor 2 (lung), and LKLF remains a commonly used alias. The gene summary links KLF2 to a number of developmental and disease-related processes, including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and T-cell viability. Researchers studying these areas often use the KLF2 antibody, KLF2 ELISA kit or KLF2 protein as tools to follow expression and function.
KLF2 binds the CACCC box in promoters and activates transcription of targets such as HBB and NOV, making it a model for KLF-driven gene control.
KLF2 is implicated in embryonic erythropoiesis and activates the beta globin gene HBB through its promoter CACCC box.
KLF2 plays a role in inflammation and T-cell viability, making it relevant to immune regulation studies.
Expressed early in mammalian development, KLF2 contributes to adipogenesis and epithelial integrity, supporting developmental and tissue biology research.
KLF2 is a nuclear transcription factor that binds the CACCC box in the promoters of target genes, including HBB and NOV, and activates their transcription. It may also modulate the binding of RARA to RARE DNA elements, influencing transcriptional regulation.
KLF2 stands for KLF transcription factor 2. Its protein name is Krueppel-like factor 2, and LKLF is a recorded alias. Earlier gene names include Kruppel-like factor 2 (lung) and Kruppel like factor 2.
Mouse and rat both have a Klf2 ortholog, so the gene is studied in rodent models; check the datasheet of any product for its validated reactivity. The NCBI summary associates KLF2 with development and disease processes including inflammation, adipogenesis and T-cell viability.
Other KLF family transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5W3; product specifications from Assay Genie datasheets.