STK40
STK40 (serine/threonine kinase 40, also known as SgK495, SHIK and MGC4796) is a member of the Tribbles pseudokinase gene group. It may act as a negative regulator of NF-kappa-B and p53-mediated gene transcription. Browse Assay Genie's current range of STK40 research reagents below, or read on for the biology behind the target.
STK40 is a serine/threonine-protein kinase whose function is still only partly defined. UniProt annotates it as a possible negative regulator of NF-kappa-B and p53-mediated gene transcription, which places it among proteins that may restrain transcriptional programmes linked to inflammatory and stress signalling. The NCBI Gene summary predicts that it binds ATP and has protein serine/threonine kinase activity, and that it is involved in regulation of the MAPK cascade.
The STK40 protein belongs to the protein kinase superfamily and, within it, to the CAMK Ser/Thr protein kinase family. HGNC classifies it with the pseudokinases, in the Tribbles pseudokinase family. Pseudokinases resemble catalytically active kinases in sequence, so the predicted enzymatic activity is best read alongside this classification. In cells, STK40 is located in the nucleus and cytoplasm; the NCBI summary describes it in the cytosol and nucleoplasm.
Genetic and functional annotation suggests that STK40 acts upstream of or within several processes, including glycogen metabolic process, lung development and respiratory system process. The STK40 gene has the aliases SgK495, SHIK and MGC4796, and the mouse and rat orthologues are both named Stk40, which allows comparative work in rodent models. Researchers studying NF-kappa-B, p53 or MAPK signalling, or the Tribbles group of pseudokinases, may use STK40 antibody, STK40 ELISA kit and recombinant STK40 protein reagents to examine its expression and role.
STK40 may negatively regulate NF-kappa-B and p53-mediated gene transcription, making it relevant to work on how these transcription programmes are controlled.
STK40 is predicted to be involved in regulation of the MAPK cascade, so it is of interest in kinase signalling research.
As a member of the Tribbles pseudokinase family, STK40 is a useful subject for comparing pseudokinase and active kinase features.
STK40 is annotated as acting within lung development, respiratory system process and glycogen metabolic process, supporting developmental and metabolic studies.
UniProt describes STK40 as a possible negative regulator of NF-kappa-B and p53-mediated gene transcription. The NCBI Gene summary also predicts ATP binding, serine/threonine kinase activity and a role in regulating the MAPK cascade. Most of these functions are predicted, not established.
STK40 stands for serine/threonine kinase 40. Its aliases and previous symbols are MGC4796, SgK495 and SHIK. UniProt names the protein serine/threonine-protein kinase 40. Searching under any of these names should help you find the same gene and protein in the literature.
Yes. Mouse and rat both have an orthologous gene named Stk40, so rodent models can be used for comparative work. HGNC places the human protein in the Tribbles pseudokinase family. Check the datasheet of any product for its validated reactivity.
Other serine/threonine kinases that sit alongside STK40 in kinase signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N2I9; product specifications from Assay Genie datasheets.