ZRANB2
ZRANB2 (zinc finger RANBP2-type containing 2) is a nuclear splice factor that binds single-stranded RNA and is required for alternative splicing of TRA2B/SFRS10 transcripts. It is also known as ZNF265, ZIS, ZIS1 and ZIS2. Browse Assay Genie's current range of ZRANB2 research reagents below, or read on for the biology behind the target.
ZRANB2 functions as a splice factor. UniProt annotation describes it as required for alternative splicing of TRA2B/SFRS10 transcripts, and it binds single-stranded RNA containing the consensus sequence 5'-AGGUAA-3'. It may also interfere with constitutive 5'-splice site selection. Consistent with this, NCBI Gene summarises the protein as enabling RNA binding activity and as predicted to be involved in RNA splicing and mRNA processing.
The ZRANB2 protein is localised to the nucleus, and NCBI Gene places it in the nucleoplasm. It belongs to the ZRANB2 family. The ZRANB2 gene is classed by HGNC within the RANBP2-type zinc finger group, which reflects the zinc finger Ran-binding domain that gives the protein its name. HGNC also lists the gene among the microRNA protein coding host genes.
The gene has been known under several names, including zinc finger protein 265 (ZNF265) and the symbols ZIS, ZIS1 and ZIS2. Mouse and rat both carry a Zranb2 ortholog. Researchers studying ZRANB2 are typically interested in how an RNA-binding nuclear protein contributes to splice-site choice and to the regulation of splicing factor transcripts such as TRA2B.
ZRANB2 is required for alternative splicing of TRA2B/SFRS10 transcripts, making it a useful subject for studying splice factor regulation.
ZRANB2 binds single-stranded RNA containing the consensus sequence 5'-AGGUAA-3', allowing sequence-specific RNA recognition to be examined.
ZRANB2 may interfere with constitutive 5'-splice site selection, which makes it relevant to work on how splice sites are chosen.
ZRANB2 is predicted to act in RNA splicing and mRNA processing and is located in the nucleoplasm, supporting studies of nuclear RNA handling.
ZRANB2 is a splice factor. It is required for alternative splicing of TRA2B/SFRS10 transcripts and binds single-stranded RNA containing the consensus sequence 5'-AGGUAA-3'. It may also interfere with constitutive 5'-splice site selection. It acts in the nucleus.
ZRANB2 is the HGNC symbol for zinc finger RANBP2-type containing 2. Aliases and previous symbols include ZIS, ZIS1, ZIS2 and ZNF265. Previous names are zinc finger protein 265 and zinc finger, RAN-binding domain containing 2. UniProt calls the protein zinc finger Ran-binding domain-containing protein 2.
Yes. Both mouse and rat have an ortholog named Zranb2, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Splicing factors, RNA-binding proteins and RANBP2-type zinc finger proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95218; product specifications from Assay Genie datasheets.