HTR1B
HTR1B (5-hydroxytryptamine receptor 1B, also known as 5-HT1B, S12, HTR1D2 and 5-HT1DB) is a G protein-coupled receptor for serotonin. It couples to G(i)/G(o) proteins to mediate inhibitory neurotransmission and regulates neurotransmitter release in the brain. Browse Assay Genie's current range of HTR1B research reagents below, or read on for the biology behind the target.
HTR1B is a G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Ligand binding causes a conformational change that triggers signalling through guanine nucleotide-binding proteins (G proteins) and modulates downstream effectors such as adenylate cyclase. The receptor is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signalling via G proteins and mediate activation of alternative signalling pathways.
In the brain, HTR1B regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine, and through this affects neural activity, nociceptive processing, pain perception, mood and behaviour. It also plays a role in vasoconstriction of cerebral arteries. Besides serotonin, the receptor binds ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, including lysergic acid diethylamide (LSD). The protein is found at the cell membrane and belongs to the G protein-coupled receptor 1 family.
The HTR1B gene is intronless and sits in the HGNC group of 5-hydroxytryptamine receptors, G protein-coupled. Earlier names include 5-hydroxytryptamine (serotonin) receptor 1B, and the symbols S12, HTR1D2 and 5-HT1DB have also been used. According to the NCBI Gene summary, the encoded protein may be involved in several neuropsychiatric disorders and is often a target of antidepressant and other psychotherapeutic drugs. Mouse and rat both carry an orthologous Htr1b gene, which makes rodent models a common route for studying receptor function.
HTR1B binds antidepressant, anxiolytic and other psychoactive compounds, and is often a target of psychotherapeutic drugs.
The receptor regulates release of serotonin, dopamine and acetylcholine in the brain, making it relevant to inhibitory neurotransmission studies.
HTR1B affects nociceptive processing, pain perception, mood and behaviour, and may be involved in neuropsychiatric disorders.
G(i)/G(o) coupling, adenylate cyclase inhibition and arrestin-mediated alternative pathways make HTR1B a useful model of GPCR signalling.
HTR1B is a serotonin-activated G protein-coupled receptor that signals through G(i)/G(o) proteins to inhibit adenylate cyclase. It regulates release of serotonin, dopamine and acetylcholine in the brain, affecting pain perception, mood and behaviour, and contributes to vasoconstriction of cerebral arteries.
HTR1B is also called 5-HT1B, S12, HTR1D2 and 5-HT1DB. Its HGNC name is 5-hydroxytryptamine receptor 1B, and it was previously described as 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled. Check the datasheet of any product for its validated reactivity.
The NCBI Gene summary notes that HTR1B may be involved in several neuropsychiatric disorders and is often targeted by antidepressant and other psychotherapeutic drugs. Mouse and rat each have an orthologous gene named Htr1b.
Other 5-hydroxytryptamine receptors and serotonin signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P28222; product specifications from Assay Genie datasheets.