SUSD2
SUSD2 (sushi domain containing 2) is a cell membrane protein of the sushi domain containing gene group, also known as W5C5, BK65A6.2 and FLJ22778. It may act as a cytokine receptor for GPR15LG and has been linked to growth suppression in cancer cells. Browse Assay Genie's current range of SUSD2 research reagents below, or read on for the biology behind the target.
SUSD2 may function as a cytokine receptor for GPR15LG. According to UniProt, it may also act as a tumour suppressor: together with GPR15LG, it has a growth-inhibitory effect on colon cancer cells, which includes G1 cell cycle arrest. These roles are annotated as possible rather than firmly established, and the receptor function in particular remains to be fully defined.
The NCBI Gene summary describes SUSD2 as involved in the negative regulation of the cell cycle G1/S phase transition and the negative regulation of cell division, and places the protein at the plasma membrane. This fits the UniProt annotation of a cell membrane protein that influences proliferation. UniProt additionally notes that SUSD2 may play a role in breast tumorigenesis, which makes it a point of interest for researchers studying how membrane proteins shape tumour cell growth.
The SUSD2 gene belongs to the HGNC group of sushi domain containing genes, and the protein is also known as sushi domain-containing protein 2, W5C5, BK65A6.2 and FLJ22778. A mouse ortholog, Susd2, is recorded. Researchers studying SUSD2 typically look at its membrane localisation, its relationship with GPR15LG and its effects on the G1/S transition in cancer models.
SUSD2 together with GPR15LG has a growth-inhibitory effect on colon cancer cells, including G1 cell cycle arrest.
UniProt notes that SUSD2 may play a role in breast tumorigenesis, making it a candidate for studies of breast cancer development.
SUSD2 is involved in negative regulation of the G1/S phase transition and of cell division.
SUSD2 is a plasma membrane protein that may act as a cytokine receptor for GPR15LG, relevant to ligand-receptor signalling research.
SUSD2 is a cell membrane protein that may act as a cytokine receptor for GPR15LG. It is also annotated as a possible tumour suppressor, and is involved in negative regulation of the G1/S cell cycle transition and of cell division.
SUSD2 stands for sushi domain containing 2, and UniProt names the protein sushi domain-containing protein 2. Other aliases include W5C5, BK65A6.2 and FLJ22778. HGNC lists no previous names, and the gene belongs to the sushi domain containing group.
UniProt reports that SUSD2 may be a tumour suppressor in colon cancer cells, with GPR15LG, and may play a role in breast tumorigenesis. A mouse ortholog, Susd2, exists. Check the datasheet of any product for its validated reactivity.
GPR15LG and other proteins linked to SUSD2 signalling and cell cycle control, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UGT4; product specifications from Assay Genie datasheets.