ADAM8
ADAM8 (ADAM metallopeptidase domain 8, also known as CD156, CD156A and MS2) is a membrane-anchored member of the ADAM family of disintegrin metalloproteinases. It has been linked to leukocyte extravasation and to cell adhesion processes. Browse Assay Genie's current range of ADAM8 research reagents below, or read on for the biology behind the target.
ADAM8 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins that are structurally related to snake venom disintegrins. They have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilisation, muscle development and neurogenesis. UniProt annotates ADAM8 as a possible participant in the extravasation of leukocytes, and it is classified as a metalloproteinase under EC 3.4.24.-.
The human ADAM8 gene encodes disintegrin and metalloproteinase domain-containing protein 8, which is located at the membrane. According to the NCBI Gene summary, the ADAM8 protein may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing of the gene results in multiple transcript variants. A mouse ortholog, Adam8, is recorded for the gene.
HGNC places the gene in the ADAM metallopeptidase domain containing group and in the CD molecules group. The previous name was a disintegrin and metalloproteinase domain 8, and the aliases CD156, CD156A and MS2 are still found in the literature. Researchers studying leukocyte trafficking, cell adhesion or airway disease will find ADAM8 relevant alongside other ADAM family members.
ADAM8 is annotated as possibly involved in the extravasation of leukocytes, making it a candidate for studies of immune cell movement out of the vasculature.
As a membrane-anchored ADAM family member, ADAM8 is relevant to cell-cell and cell-matrix interactions, including adhesion during neurodegeneration.
ADAM8 is thought to be a target for allergic respiratory diseases, including asthma, which makes it a focus for airway inflammation research.
ADAM proteins are linked to fertilisation, muscle development and neurogenesis, so ADAM8 offers a point of comparison within this metalloproteinase family.
ADAM8 is a membrane-anchored ADAM family metalloproteinase. UniProt describes a possible involvement in the extravasation of leukocytes. The NCBI Gene summary adds that it may be involved in cell adhesion during neurodegeneration and is thought to be a target for allergic respiratory diseases, including asthma.
ADAM8 is also called CD156, CD156A and MS2. Its full HGNC name is ADAM metallopeptidase domain 8, and the previous name was a disintegrin and metalloproteinase domain 8. Alternative splicing of the gene produces multiple transcript variants.
A mouse ortholog, Adam8, is recorded for the human gene. ADAM8 belongs to the ADAM family, whose members are structurally related to snake venom disintegrins. Check the datasheet of any product for its validated reactivity.
Other ADAM family metalloproteinases and related ADAMTS proteases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78325; product specifications from Assay Genie datasheets.