TFF2
TFF2 (trefoil factor 2, also known as SML1 and previously named spasmolytic protein 1) is a stable secreted protein of the gastrointestinal mucosa. It inhibits gastrointestinal motility and gastric acid secretion, and may contribute to the structure of gastric mucus. Browse Assay Genie's current range of TFF2 research reagents below, or read on for the biology behind the target.
TFF2 inhibits gastrointestinal motility and gastric acid secretion. It could also act as a structural component of gastric mucus, possibly by stabilising glycoproteins in the mucus gel through interactions with their carbohydrate side chains. The TFF2 protein is therefore of interest to researchers studying the mucosal barrier of the digestive tract.
TFF2 belongs to the trefoil family. Members of this family carry at least one copy of the trefoil motif, a 40-amino acid domain containing three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not fully defined, but they may protect the mucosa from insults, stabilise the mucus layer and affect healing of the epithelium. The mature TFF2 gene product is secreted, consistent with a role in the mucus layer that lines the gastric surface.
The TFF2 gene lies in a cluster on chromosome 21 with two other related trefoil family genes, one of which is TFF1. The protein was originally named spasmolytic protein 1, reflecting its inhibitory effect on gastrointestinal motility, and the alias SML1 derives from that name. Orthologous genes, designated Tff2, are found in mouse and rat, which allows the biology of this trefoil factor to be studied in rodent models of gastric physiology.
TFF2 is a secreted trefoil protein of gastrointestinal mucosa that may protect the mucosa from insults.
TFF2 may stabilise glycoproteins in the mucus gel through interactions with carbohydrate side chains.
TFF2 inhibits gastric acid secretion and gastrointestinal motility, making it relevant to digestive physiology.
Trefoil family proteins may affect healing of the epithelium, a process studied through TFF2 expression and function.
TFF2 inhibits gastrointestinal motility and gastric acid secretion. It may also serve as a structural component of gastric mucus, possibly stabilising glycoproteins in the mucus gel through interactions with carbohydrate side chains. Trefoil family functions are not fully defined.
The official name is trefoil factor 2. The gene has the alias SML1, and the protein was previously called spasmolytic protein 1. The UniProt entry uses the name Trefoil factor 2, and the protein is a secreted product.
Mouse and rat both have a Tff2 ortholog. In humans, the TFF2 gene sits in a cluster on chromosome 21 with two other trefoil family genes, including TFF1. Check the datasheet of any product for its validated reactivity.
Another trefoil family member encoded in the same chromosome 21 gene cluster, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q03403; product specifications from Assay Genie datasheets.