SLC4A5
SLC4A5 (solute carrier family 4 member 5, also known as NBC4) is an integral membrane sodium bicarbonate cotransporter. It mediates sodium- and bicarbonate-dependent electrogenic transport and belongs to the anion exchanger family. Browse Assay Genie's current range of SLC4A5 research reagents below, or read on for the biology behind the target.
SLC4A5 mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport. Its Na(+):HCO3(-) stoichiometry is reported to vary from 1:2 to 1:3, so the transport it carries is electrogenic and moves net charge across the membrane. Sodium bicarbonate cotransporters of this kind are involved in intracellular pH regulation and in electroneural or electrogenic sodium bicarbonate transport.
The SLC4A5 gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, which forms part of the bicarbonate transporter superfamily. The SLC4A5 protein is thought to be an integral membrane protein, and UniProt annotates it at both the apical and the basolateral cell membrane. It belongs to the anion exchanger (TC 2.A.31) family and sits within the HGNC solute carrier family 4 gene group. Multiple transcript variants encoding different isoforms have been found, although the biological validity of some variants has not been determined.
The protein is listed by UniProt as electrogenic sodium bicarbonate cotransporter 4, and the symbol NBC4 is a previous name for the gene. Earlier HGNC names described it as solute carrier family 4, sodium bicarbonate cotransporter, member 5. Orthologous genes named Slc4a5 are annotated in both mouse and rat, which allows the SLC4A5 gene to be studied in rodent systems.
Sodium bicarbonate cotransporters are involved in intracellular pH regulation, making SLC4A5 a relevant target for studying how cells handle bicarbonate.
SLC4A5 is found at both apical and basolateral cell membranes, which is relevant to studies of polarised bicarbonate transport.
With a Na(+):HCO3(-) stoichiometry from 1:2 to 1:3, SLC4A5 is a useful model for electrogenic cotransport.
As an anion exchanger family member in the bicarbonate transporter superfamily, SLC4A5 supports comparative work across solute carrier transporters.
SLC4A5 mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry that varies from 1:2 to 1:3. Cotransporters of this type are involved in intracellular pH regulation and in sodium bicarbonate transport across membranes.
Yes. NBC4 is a previous symbol for the gene now named SLC4A5, and UniProt lists the protein as electrogenic sodium bicarbonate cotransporter 4. Multiple transcript variants encoding different isoforms have been reported, though the validity of some has not been determined.
Orthologous genes named Slc4a5 are annotated in both mouse and rat. Researchers working in rodent models should check the datasheet of any product for its validated reactivity before choosing a reagent.
Other solute carrier transporters involved in ion, pH and solute transport across cell membranes.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BY07; product specifications from Assay Genie datasheets.