CLEC4D
CLEC4D (C-type lectin domain family 4 member D, also known as Dectin-3, MCL, CD368, CLECSF8 and Mpcl) is a calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. It recognises bacterial and fungal ligands on the surface of myeloid cells. Browse Assay Genie's current range of CLEC4D research reagents below, or read on for the biology behind the target.
CLEC4D is a calcium-dependent lectin that functions as a pattern recognition receptor (PRR). It recognises damage-associated and pathogen-associated molecular patterns from bacteria and fungi, including alpha-mannans on C. albicans hyphae and mycobacterial trehalose 6,6'-dimycolate (TDM). The receptor interacts with the signalling adapter Fc receptor gamma chain (FCER1G), likely via CLEC4E, to form a functional complex in myeloid cells.
Ligand binding to this complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G. This triggers activation of SYK, CARD9 and NF-kappa-B, which drives maturation of antigen-presenting cells and shapes antigen-specific priming of T cells towards effector T-helper 1 and T-helper 17 subtypes. The heterodimer formed with CLEC6A is active against fungal infection. CLEC4D also works as an endocytic receptor and may be involved in antigen uptake at the site of infection, either for clearance or for processing and presentation to T cells.
The CLEC4D gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse roles, including cell adhesion, cell-cell signalling, glycoprotein turnover, inflammation and immune response. The gene lies in the natural killer gene complex region, closely linked to other superfamily members. HGNC places it among the CD molecules and the Dectin 2 cluster of C-type lectin domain containing genes. Older names include C-type lectin superfamily member 8 (CLECSF8). Mouse and rat both carry a Clec4d ortholog.
CLEC4D is a pattern recognition receptor that senses bacterial and fungal molecular patterns on myeloid cells.
CLEC4D binds C. albicans alpha-mannans, and its heterodimer with CLEC6A is active against fungal infection.
The receptor recognises mycobacterial trehalose 6,6'-dimycolate, linking glycolipid sensing to SYK, CARD9 and NF-kappa-B signalling.
CLEC4D signalling shapes T-helper 1 and T-helper 17 priming, and the receptor may mediate antigen uptake as an endocytic receptor.
CLEC4D is a calcium-dependent pattern recognition receptor of the innate immune system. It recognises bacterial and fungal patterns such as C. albicans alpha-mannans and mycobacterial TDM, signals through FCER1G, SYK, CARD9 and NF-kappa-B, and may act as an endocytic receptor for antigen uptake.
CLEC4D is also called Dectin-3, MCL, CD368, CLECSF8 and Mpcl. Its previous full name was C-type lectin superfamily member 8, and it is listed among the CD molecules and the Dectin 2 cluster. Check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat both have a Clec4d ortholog. The human gene belongs to the C-type lectin/C-type lectin-like domain superfamily and sits in the natural killer gene complex region on chromosome 12p13. Check the datasheet of any product for its validated reactivity.
Other C-type lectin receptors, including CLEC4D's likely complex partner CLEC4E and its heterodimer partner CLEC6A, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WXI8; product specifications from Assay Genie datasheets.