RPS9
RPS9 (ribosomal protein S9, also known as S9 or uS4) is a component of the 40S small ribosomal subunit, the part of the ribosome involved in protein synthesis. It also takes part in the assembly of the small subunit processome in the nucleolus. Browse Assay Genie's current range of RPS9 research reagents below, or read on for the biology behind the target.
RPS9 is a component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Eukaryotic ribosomes consist of a small 40S subunit and a large 60S subunit, which together contain four RNA species and approximately 80 structurally distinct proteins. The RPS9 protein is one of those proteins and is part of the 40S subunit.
RPS9 is also part of the small subunit (SSU) processome, the first precursor of the small eukaryotic ribosomal subunit. During SSU processome assembly in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA. Together they generate RNA folding, modifications, rearrangements and cleavage, as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Consistent with this role, UniProt records the protein in both the cytoplasm and the nucleolus of the nucleus.
The RPS9 gene encodes a protein of the S4P family, called the universal ribosomal protein uS4 family in current nomenclature, and HGNC places it in the S ribosomal proteins gene group. Variable expression of the RPS9 gene has been observed in colorectal cancers compared with adjacent normal tissues, although no correlation between expression level and disease severity has been found. As is typical for ribosomal protein genes, multiple processed pseudogenes derived from RPS9 are dispersed through the genome. Mouse and rat each have an Rps9 ortholog.
RPS9 associates with nascent pre-rRNA during SSU processome assembly in the nucleolus, making it relevant to studies of small subunit formation.
As a 40S subunit component, RPS9 contributes to the ribosome, the complex responsible for protein synthesis in the cell.
Variable RPS9 expression has been reported in colorectal cancers compared with adjacent normal tissue, though it does not correlate with disease severity.
RPS9 works alongside biogenesis factors and an RNA chaperone in pre-rRNA folding, cleavage and exosome-mediated degradation.
RPS9 is a component of the 40S small ribosomal subunit, which forms part of the ribosome that synthesises proteins. It is also part of the SSU processome, which assembles in the nucleolus on nascent pre-rRNA and is the first precursor of the small subunit.
RPS9 is the HGNC symbol for ribosomal protein S9. Other names are S9 and uS4, the latter reflecting current ribosomal protein nomenclature. UniProt lists the protein as small ribosomal subunit protein uS4, a member of the universal ribosomal protein uS4 family.
Mouse and rat both have an Rps9 ortholog, and the protein belongs to the universal uS4 family. Variable RPS9 expression has been seen in colorectal cancers versus adjacent normal tissue, without correlation to severity. Check the datasheet of any product for its validated reactivity.
Other small subunit ribosomal proteins and related ribosomal targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P46781; product specifications from Assay Genie datasheets.