TXN
TXN (thioredoxin) is a small redox protein of the thioredoxin family that acts as a homodimer in many redox reactions. It is also known as TRX, Trx80, TXN1 and ADF, the last name reflecting its effect on interleukin-2 receptor expression. Browse Assay Genie's current range of TXN research reagents below, or read on for the biology behind the target.
TXN is involved in many redox reactions and acts as a homodimer. According to the NCBI Gene summary, the encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, a process that forms part of the response to intracellular nitric oxide. UniProt also records an activity under the name ADF, in which the protein augments expression of the interleukin-2 receptor TAC (IL2R/P55).
The TXN gene encodes a member of the thioredoxin family. UniProt lists the protein in the nucleus, the cytoplasm and as a secreted protein, while the NCBI Gene summary describes it as found in the cytoplasm. Two transcript variants encoding different isoforms have been reported for the gene. Mouse and rat each carry an orthologous Txn gene, so the protein can be studied in common rodent models as well as in human systems.
The several names used for this target reflect its history of discovery and function. TRX and TXN1 are alternative symbols for the thioredoxin gene, Trx80 is another listed alias, and ADF refers to the activity that augments IL2R/P55 expression. Researchers working on TXN often study it alongside related thioredoxin-domain proteins, thioredoxin reductases and the thioredoxin-interacting protein TXNIP, which together shape cellular redox signalling.
TXN takes part in many redox reactions, making it a central protein for studying how cells handle reduction and oxidation chemistry.
TXN is active in reversible S-nitrosylation of cysteines, part of the response to intracellular nitric oxide.
As ADF, TXN augments expression of the interleukin-2 receptor TAC (IL2R/P55), linking redox proteins to receptor expression.
TXN is reported in the nucleus, cytoplasm and as a secreted protein, which makes its distribution a useful research question.
TXN (thioredoxin) acts as a homodimer in many redox reactions. It is active in the reversible S-nitrosylation of cysteines in certain proteins, part of the response to intracellular nitric oxide. As ADF, it also augments expression of the interleukin-2 receptor TAC (IL2R/P55).
TXN is also known as TRX, Trx80, TXN1 and ADF. The NCBI Gene summary reports two transcript variants that encode different isoforms. When searching the literature or choosing reagents, it helps to check these aliases alongside the approved symbol.
Yes. Mouse and rat both have an orthologous gene named Txn, so rodent models can be used to study the protein. The protein belongs to the thioredoxin family. Check the datasheet of any product for its validated reactivity.
Other thioredoxin family members, thioredoxin reductases and thioredoxin-interacting proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10599; product specifications from Assay Genie datasheets.