GAB2
GAB2 (GRB2 associated binding protein 2, also known as KIAA0571) is a scaffolding adapter protein of the GAB family. It acts downstream of cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Browse Assay Genie's current range of GAB2 research reagents below, or read on for the biology behind the target.
GAB2 is an adapter protein that sits downstream of several membrane receptors, including cytokine, antigen, hormone, cell matrix and growth factor receptors, and helps to route their signals into multiple pathways. It does not act as an enzyme. Instead, it transmits signals in response to stimuli, including those received through T- and B-cell antigen receptors. In osteoclast differentiation, GAB2 mediates TNFRSF11A/RANK signalling. In the allergic response, it contributes to mast cell activation and degranulation through regulation of PI-3-kinase, and it is described as the principal activator of phosphatidylinositol-3 kinase after activation of the high affinity IgE receptor. GAB2 is also involved in the regulation of cell proliferation and haematopoiesis.
The GAB2 gene encodes a member of the GRB2-associated binding protein (GAB) family. Like other family members, the protein contains a pleckstrin homology (PH) domain and binds the SHP2 tyrosine phosphatase and the GRB2 adapter protein. HGNC places it in the pleckstrin homology domain containing gene group. UniProt records its localisation as cytoplasm, cell membrane and membrane raft. Two alternatively spliced transcripts encoding different isoforms have been described. Mouse and rat both have a Gab2 ortholog.
The gene was previously catalogued under the symbol KIAA0571. Researchers studying the GAB2 protein typically use it as a model of receptor-proximal scaffolding, and as a way to follow PI-3-kinase-dependent signalling in immune and bone cell biology. Related work often considers GAB1, the other GAB family adapter, alongside it.
GAB2 contributes to mast cell activation and degranulation through PI-3-kinase regulation, and activates PI-3-kinase after high affinity IgE receptor stimulation.
GAB2 regulates osteoclast differentiation by mediating TNFRSF11A/RANK signalling, making it relevant to studies of bone cell development.
As an adapter downstream of cytokine, growth factor, hormone, cell matrix and antigen receptors, GAB2 helps researchers dissect how signals are routed.
GAB2 is involved in regulating cell proliferation and haematopoiesis, so it features in work on blood cell development and growth control.
GAB2 is an adapter protein that acts downstream of cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate several signalling pathways. It mediates RANK signalling in osteoclast differentiation, regulates PI-3-kinase in mast cell activation and degranulation, and is involved in proliferation and haematopoiesis.
GAB2 is the approved symbol for GRB2 associated binding protein 2, and KIAA0571 is a previous symbol for the gene. NCBI Gene reports two alternatively spliced transcripts that encode different isoforms. Check the datasheet of any product for its validated reactivity.
Mouse and rat each have an ortholog named Gab2. GAB2 belongs to the GAB family, whose members contain a pleckstrin homology domain and bind SHP2 and GRB2. GAB1 is another member of this family.
GAB1, the other GAB family adapter with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UQC2; product specifications from Assay Genie datasheets.