PGS1
PGS1 (phosphatidylglycerophosphate synthase 1, also known as DKFZP762M186) is a mitochondrial phosphatidyltransferase that functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. It is a member of the CDP-alcohol phosphatidyltransferase class-II family. Browse Assay Genie's current range of PGS1 research reagents below, or read on for the biology behind the target.
PGS1 is an enzyme that functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. Its systematic activity is that of a CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5), and the UniProt entry names the mitochondrial protein accordingly. It belongs to the CDP-alcohol phosphatidyltransferase class-II family.
The human PGS1 gene encodes a protein that UniProt assigns to the mitochondrion. The NCBI Gene summary, provided by the Alliance of Genome Resources, describes the protein as predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity and calcium ion binding activity. It is predicted to be involved in the cardiolipin biosynthetic process and in diacylglycerol metabolic process. The same summary reports that it is located in the endoplasmic reticulum and is active in the mitochondrion. The mouse ortholog is Pgs1.
Researchers studying the PGS1 gene or PGS1 protein are generally interested in mitochondrial membrane lipid synthesis, because phosphatidylglycerol and cardiolipin are both anionic phospholipids produced through this enzymatic step. The gene has the HGNC name phosphatidylglycerophosphate synthase 1 and the alias DKFZP762M186. Because several of the functional assignments for PGS1 are described as predicted, assay design for this target should take account of the current level of experimental evidence.
PGS1 is predicted to be involved in the cardiolipin biosynthetic process, making it a relevant enzyme for studying how this anionic phospholipid is produced.
UniProt annotates PGS1 as functioning in phosphatidylglycerol biosynthesis, so it is a focus for work on anionic phospholipid production.
As a mitochondrial phosphatidyltransferase, PGS1 is a natural subject for studies of lipid metabolism within the organelle, including diacylglycerol metabolic process.
PGS1 belongs to the CDP-alcohol phosphatidyltransferase class-II family and is predicted to bind calcium ions, offering a model for enzyme mechanism studies.
PGS1 functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. It is a CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) and is annotated as a mitochondrial protein.
PGS1 is the approved HGNC symbol for phosphatidylglycerophosphate synthase 1. The alias DKFZP762M186 is also used. UniProt names the protein CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial.
A mouse ortholog, Pgs1, is recorded for the human gene. The protein belongs to the CDP-alcohol phosphatidyltransferase class-II family. Check the datasheet of any product for its validated reactivity.
Other enzymes of mitochondrial phospholipid and cardiolipin metabolism with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q32NB8; product specifications from Assay Genie datasheets.