CDO1
CDO1 (cysteine dioxygenase type 1) is an oxygenase that catalyses the oxidation of cysteine to cysteine sulfinic acid. It is the rate-limiting enzyme in the catabolism of cysteine to taurine and belongs to the cysteine dioxygenase family. Browse Assay Genie's current range of CDO1 research reagents below, or read on for the biology behind the target.
CDO1 is the rate-limiting enzyme of the cysteine catabolic process that leads to taurine. It catalyses the oxidation of cysteine to cysteine sulfinic acid, adding molecular dioxygen in the reaction. This places the enzyme at the entry point of the route by which cysteine is converted to taurine, so changes in its activity bear directly on flux through that pathway.
According to NCBI Gene, the CDO1 protein enables cysteine dioxygenase activity, ferrous iron binding activity and zinc ion binding activity. It is involved in the L-cysteine catabolic process and in taurine biosynthesis, and it is predicted to be located in the cytosol. UniProt places it in the cysteine dioxygenase family, and HGNC classifies the CDO1 gene within the oxygenases group. The enzyme carries the EC number 1.13.11.20.
The approved gene name is cysteine dioxygenase type 1; the previous HGNC name was cysteine dioxygenase, type I. Orthologous genes are designated Cdo1 in both mouse and rat, which allows the enzyme to be studied in common rodent models. Researchers working on cysteine metabolism and taurine biosynthesis use a CDO1 antibody, a CDO1 ELISA kit or recombinant CDO1 protein to examine expression and activity of this step.
CDO1 catalyses the oxidation of cysteine to cysteine sulfinic acid, making it a central enzyme for studying L-cysteine breakdown.
As the rate-limiting enzyme in the route from cysteine to taurine, CDO1 is a key point for analysing taurine biosynthetic control.
CDO1 shows ferrous iron and zinc ion binding activity, which makes it relevant to studies of metal-dependent oxygenase function.
Belonging to the cysteine dioxygenase family and the HGNC oxygenases group, CDO1 supports comparative work on dioxygenase mechanisms.
CDO1 is the rate-limiting enzyme in the catabolism of cysteine to taurine. It catalyses the oxidation of cysteine to cysteine sulfinic acid with the addition of molecular dioxygen. It binds ferrous iron and zinc ions and is predicted to act in the cytosol.
The HGNC-approved name is cysteine dioxygenase type 1, and the previous name was cysteine dioxygenase, type I. No alternative gene symbols are recorded. The enzyme is classified as EC 1.13.11.20 and sits in the cysteine dioxygenase family.
Yes. Both mouse and rat carry a gene named Cdo1, so the enzyme can be studied in rodent systems. Cross-reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other cysteine metabolism enzymes and oxygenases with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16878; product specifications from Assay Genie datasheets.