EFHD1
EFHD1 (EF-hand domain family member D1, also known as FLJ13612) is a calcium-binding protein of the mitochondrial inner membrane. It acts as a calcium sensor for mitochondrial flash activation and may contribute to neuronal differentiation. Browse Assay Genie's current range of EFHD1 research reagents below, or read on for the biology behind the target.
EFHD1 acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterised by stochastic bursts of superoxide production. In HeLa cells it has been shown to function as a novel mitochondrial calcium ion sensor for this process. The protein associates with the mitochondrial inner membrane, which places it at the interface between calcium signalling and mitochondrial redox activity. UniProt also notes that it may play a role in neuronal differentiation.
The EFHD1 gene encodes a member of the EF-hand superfamily of calcium-binding proteins, a group involved in cellular processes including mitosis, synaptic transmission and cytoskeletal rearrangement. The encoded protein is composed of an N-terminal disordered region, proline-rich elements, two EF-hands and a C-terminal coiled-coil domain. Alternative splicing of the gene results in multiple transcript variants. The mouse ortholog is Efhd1.
HGNC classifies the protein in the EF-hand domain containing gene group. The gene was previously named EF hand domain containing 1 and carries the alias FLJ13612. Researchers studying EFHD1 are typically interested in mitochondrial calcium handling, superoxide bursts and neuronal differentiation. A related EF-hand domain family member, EFHD2, is also a target of research interest.
EFHD1 is a calcium sensor associated with the mitochondrial inner membrane, making it relevant to studies of how calcium is decoded inside mitochondria.
The protein acts as a calcium sensor for mitoflash activation, a stochastic burst of superoxide production, linking it to mitochondrial redox research.
UniProt reports that EFHD1 may play a role in neuronal differentiation, supporting its study in neural development and differentiation models.
As an EF-hand superfamily member, EFHD1 provides a model for calcium-binding proteins involved in mitosis, synaptic transmission and cytoskeletal rearrangement.
EFHD1 acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event marked by stochastic bursts of superoxide production. In HeLa cells it behaves as a mitochondrial calcium ion sensor. It may also play a role in neuronal differentiation.
EFHD1 stands for EF-hand domain family member D1; UniProt calls it EF-hand domain-containing protein D1. The alias FLJ13612 and the former name EF hand domain containing 1 also appear in the literature. Alternative splicing of the gene produces multiple transcript variants.
A mouse ortholog, Efhd1, is annotated for the human gene, so rodent models can be used to study its biology. Always check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other EF-hand domain family members and calcium-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BUP0; product specifications from Assay Genie datasheets.