NKp30
NKp30 (natural cytotoxicity triggering receptor 3, encoded by NCR3) is a cell membrane receptor of natural killer cells that stimulates cytotoxicity toward cells expressing its ligands. It is also known as CD337, 1C7 and LY117. Browse Assay Genie's current range of NKp30 research reagents below, or read on for the biology behind the target.
NKp30 is a cell membrane receptor of natural killer (NK) cells. It is activated by the binding of extracellular ligands, including BAG6 and NCR3LG1, and in response stimulates NK cell cytotoxicity toward neighbouring cells that produce these ligands. This makes NKp30 a control point for NK cell cytotoxicity against tumour cells. The NKp30 protein interacts with CD3-zeta (CD247), a T-cell receptor component.
NKp30 also has a role beyond direct killing. When BAG6 engages NKp30, myeloid dendritic cell (DC) maturation is promoted. This happens in two ways: NK cells kill DCs that have not acquired a mature phenotype, and they release TNF-alpha and IFN-gamma, which promote DC maturation. The receptor therefore links NK cell activity to the shaping of dendritic cell populations.
The NKp30 gene, NCR3, belongs to the natural cytotoxicity receptor (NCR) family and is classed by HGNC within the CD molecules and V-set domain containing groups. Three transcript variants encoding different isoforms have been reported. A single nucleotide polymorphism in the 5' untranslated region of the gene has been associated with mild malaria susceptibility. NKp30 was previously named lymphocyte antigen 117, and the CD designation is CD337. A rat ortholog, Ncr3, is listed in the data.
NKp30 controls NK cell cytotoxicity against tumour cells and may aid their lysis, making it a focus for studies of NK cell anti-tumour activity.
The receptor couples to CD3-zeta (CD247) and is triggered by ligands such as BAG6 and NCR3LG1, which supports work on activating receptor pathways.
Engagement of NKp30 by BAG6 promotes DC maturation through killing of immature DCs and release of TNF-alpha and IFN-gamma by NK cells.
A 5' untranslated region polymorphism in NCR3 has been associated with mild malaria susceptibility, linking the gene to host-response studies.
NKp30 is a cell membrane receptor on natural killer cells. Binding of ligands such as BAG6 and NCR3LG1 activates it and stimulates NK cell cytotoxicity toward cells producing those ligands, including tumour cells. It also promotes dendritic cell maturation when engaged by BAG6.
NKp30 is encoded by NCR3 and is also called CD337, 1C7 and LY117. Its previous name was lymphocyte antigen 117. Three transcript variants encoding different isoforms have been described for the gene.
A single nucleotide polymorphism in the 5' untranslated region of NCR3 has been associated with mild malaria susceptibility. A rat ortholog, Ncr3, is listed, while no mouse ortholog is recorded in the data. Check the datasheet of any product for its validated reactivity.
Other natural cytotoxicity receptors and NK cell signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14931; product specifications from Assay Genie datasheets.