BMP-3
BMP-3 (bone morphogenetic protein 3) is a secreted growth factor of the TGF-beta superfamily that helps pattern early skeletal formation and negatively regulates bone density. It was previously named bone morphogenetic protein 3 (osteogenic) and is encoded by the BMP3 gene. Browse Assay Genie's current range of BMP-3 research reagents below, or read on for the biology behind the target.
BMP-3 is a growth factor of the TGF-beta superfamily with an essential role in development, where it induces and patterns early skeletal formation. Unlike many members of the bone morphogenetic protein group, it negatively regulates bone density. It antagonises the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification, and it suppresses osteoblast differentiation by modulating the availability of TGF-beta receptors to other ligands.
Like other ligands of this family, BMP-3 acts through receptor binding and downstream SMAD signalling. It initiates signalling cascades by associating with the type II receptor ACVR2B, activating SMAD2-dependent and SMAD-independent routes, including the TAK1 and JNK pathways. Ligands of the family generally bind TGF-beta receptors, leading to recruitment and activation of SMAD transcription factors that regulate gene expression.
The BMP3 gene encodes a secreted preproprotein that is proteolytically processed to generate the subunits of a disulfide-linked homodimer. BMP-3 belongs to the HGNC gene group of bone morphogenetic proteins, and orthologues are annotated in mouse (Bmp3) and rat (Bmp3). Its opposing action to osteogenic BMPs makes it a useful reference point when studying how signalling balance shapes bone formation.
BMP-3 induces and patterns early skeletal formation, making it relevant to studies of how the skeleton is established during development.
BMP-3 negatively regulates bone density, so it is studied in work on the control of bone mass.
BMP-3 suppresses osteoblast differentiation and antagonises osteogenic BMPs in osteoprogenitor differentiation and ossification.
BMP-3 signals via ACVR2B to SMAD2, TAK1 and JNK pathways, and modulates receptor availability to other ligands.
BMP-3 is a secreted TGF-beta superfamily growth factor that patterns early skeletal formation and negatively regulates bone density. It antagonises certain osteogenic BMPs and suppresses osteoblast differentiation, partly by modulating the availability of TGF-beta receptors to other ligands.
The HGNC name is bone morphogenetic protein 3, previously bone morphogenetic protein 3 (osteogenic); the gene symbol is BMP3. The encoded preproprotein is proteolytically processed to generate the subunits of a disulfide-linked homodimer, which is secreted.
Yes. Mouse and rat both have an orthologous gene, Bmp3. Researchers working in rodent models should check the datasheet of any product for its validated reactivity before use.
Other bone morphogenetic proteins, BMP receptors and regulators relevant to TGF-beta superfamily and skeletal biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P12645; product specifications from Assay Genie datasheets.