SLC6A19
SLC6A19, also known as B0AT1, is a sodium-dependent transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. It is a member of the solute carrier family 6 and a system B(0) transmembrane protein. Browse Assay Genie's current range of SLC6A19 research reagents below, or read on for the biology behind the target.
SLC6A19 is a transmembrane transporter that actively moves most neutral amino acids across the apical membrane of epithelial cells. In the kidney and intestine it mediates amino acid resorption. This uptake is sodium-dependent and chloride-independent. The protein is classed as a system B(0) transporter and belongs to the sodium:neurotransmitter symporter (SNF) family, in the SLC6A19 subfamily.
The SLC6A19 protein, also called B0AT1 or sodium-dependent neutral amino acid transporter B(0)AT1, needs an accessory partner to reach the cell surface and work. In the kidney it requires CLTRN. In the intestine it requires ACE2, which acts as a chaperone for membrane trafficking of B0AT1. Expression and function of B0AT1 in intestinal cells therefore depend on ACE2. ACE2 is also the cellular receptor for SARS-CoV and SARS-CoV-2, which links this transporter to coronavirus research.
The SLC6A19 gene is a member of the solute carrier family 6 group. Its earlier HGNC name was solute carrier family 6 (neutral amino acid transporter), member 19. Mutations in the gene may result in Hartnup disorder, an inherited disease with symptoms such as pellagra, cerebellar ataxia and psychosis. Orthologous genes are annotated in mouse and rat as Slc6a19, so the protein can be studied in rodent models as well as in human material.
SLC6A19 mediates resorption of neutral amino acids across the apical membrane of renal epithelial cells, with CLTRN needed for its surface expression in kidney.
In the intestine, SLC6A19 takes up neutral amino acids at the apical membrane and depends on ACE2 for cell surface expression and activity.
Mutations in SLC6A19 may cause Hartnup disorder, an inherited condition marked by pellagra, cerebellar ataxia and psychosis.
ACE2 chaperones B0AT1 trafficking and is the receptor for SARS-CoV and SARS-CoV-2, making the pair relevant to studies of receptor partnerships.
SLC6A19 transports neutral amino acids across the apical membrane of renal and intestinal epithelial cells, mediating their resorption. Uptake is sodium-dependent and chloride-independent. It needs CLTRN in kidney or ACE2 in intestine for cell surface expression and transporter activity.
SLC6A19 is also called B0AT1, and its UniProt name is sodium-dependent neutral amino acid transporter B(0)AT1. The HGNC full name is solute carrier family 6 member 19, previously solute carrier family 6 (neutral amino acid transporter), member 19.
Mutations in the SLC6A19 gene may result in Hartnup disorder, with symptoms including pellagra, cerebellar ataxia and psychosis. Mouse and rat both have a Slc6a19 ortholog; check the datasheet of any product for its validated reactivity.
Other solute carrier transporters, including amino acid and epithelial transport proteins, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q695T7; product specifications from Assay Genie datasheets.