MAP3K2
MAP3K2 (mitogen-activated protein kinase kinase kinase 2, also known as MEKK2 and MEKK2B) is a serine/threonine protein kinase that acts as a component of a kinase signal transduction cascade. It activates downstream kinases in MAP kinase signalling, including the JNK and ERK5 pathways. Browse Assay Genie's current range of MAP3K2 research reagents below, or read on for the biology behind the target.
MAP3K2 is a component of a protein kinase signal transduction cascade. It regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. According to the NCBI Gene summary, the kinase preferentially activates other kinases involved in the MAP kinase signalling pathway. It has also been shown to phosphorylate and activate Ikappa B kinases directly, which links it to NF-kappa B signalling.
The protein is a member of the serine/threonine protein kinase family. It belongs to the protein kinase superfamily, the STE Ser/Thr protein kinase family and the MAP kinase kinase kinase subfamily. HGNC places the MAP3K2 gene in the group of mitogen-activated protein kinase kinase kinases, within the STE11 kinase family. UniProt records the MAP3K2 protein in the cytoplasm and the nucleus. The mouse ortholog is Map3k2.
MAP3K2 has been found to bind and activate protein kinase C-related kinase 2. This suggests that it takes part in a regulated signalling process. UniProt also annotates a role for MAP3K2 in caveolae kiss-and-run dynamics. The symbols MEKK2 and MEKK2B are used for this gene in the literature, and researchers studying MAP kinase cascades, stress signalling or NF-kappa B regulation will meet MAP3K2 under these names.
MAP3K2 sits at the top of a kinase cascade and activates MAP2K5 and MAP2K7, making it a useful node for studying MAP kinase signal transmission.
The kinase regulates the JNK and ERK5 pathways through phosphorylation of MAP2K7 and MAP2K5, so it is relevant to dissecting how each branch is activated.
MAP3K2 directly phosphorylates and activates Ikappa B kinases, giving it a role in the NF-kappa B signalling pathway.
UniProt annotates a role for MAP3K2 in caveolae kiss-and-run dynamics, linking kinase signalling to membrane trafficking research.
MAP3K2 is a serine/threonine kinase in a signal transduction cascade. It regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. It also activates Ikappa B kinases, linking it to NF-kappa B signalling, and plays a role in caveolae kiss-and-run dynamics.
MAP3K2 is also called MEKK2 and MEKK2B, and its full name is mitogen-activated protein kinase kinase kinase 2. HGNC lists no previous gene names. The enzyme carries the EC number 2.7.11.25, and the gene belongs to the STE11 kinase family group.
A mouse ortholog, Map3k2, is recorded for the human gene. The protein belongs to the STE Ser/Thr protein kinase family and the MAP kinase kinase kinase subfamily. Check the datasheet of any product for its validated reactivity.
Other MAP kinase kinase kinases, their MAP2K substrates and related signalling kinases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y2U5; product specifications from Assay Genie datasheets.