CDH16
CDH16 (cadherin 16, also known as KSP-cadherin) is a calcium-dependent, membrane-associated cell adhesion glycoprotein of the cadherin superfamily. It is expressed exclusively in kidney, where it mediates homotypic cellular recognition during tissue development. Browse Assay Genie's current range of CDH16 research reagents below, or read on for the biology behind the target.
CDH16 is a calcium-dependent cell adhesion protein. Like other cadherins, it preferentially interacts with itself in a homophilic manner when connecting cells, and cadherins may therefore contribute to the sorting of heterogeneous cell types. According to the NCBI Gene summary, CDH16 is the principal mediator of homotypic cellular recognition in kidney and plays a role in the morphogenic direction of tissue development.
The CDH16 gene encodes a membrane-associated glycoprotein with an extracellular domain containing six cadherin domains, a transmembrane region and a truncated cytoplasmic domain. It lacks the prosequence and the tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is reported to be exclusively in kidney. Alternatively spliced transcript variants encoding distinct isoforms have been identified. The mouse ortholog is Cdh16.
The CDH16 gene maps to a previously identified cluster of cadherin genes on chromosome 16q22.1, alongside superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. HGNC places it in the 7D cadherins group, and lists the previous name KSP-cadherin. Researchers studying kidney development, epithelial adhesion and cadherin biology use CDH16 as a kidney-specific member of the superfamily.
CDH16 plays a role in the morphogenic direction of tissue development in kidney, making it relevant to studies of renal tissue organisation.
As a calcium-dependent cadherin that interacts homophilically, CDH16 is a model for how adhesion proteins connect cells and sort cell types.
CDH16 lacks the prosequence and HAV recognition motif typical of classical cadherins, offering a point of comparison across the superfamily.
Its expression exclusively in kidney makes CDH16 a useful target for work on kidney-specific gene expression and cellular recognition.
CDH16 is a calcium-dependent cell adhesion protein that interacts preferentially with itself in a homophilic manner. In kidney, where it is exclusively expressed, it acts as the principal mediator of homotypic cellular recognition and contributes to the morphogenic direction of tissue development.
KSP-cadherin is a previous name for CDH16, whose HGNC name is cadherin 16. The NCBI Gene summary notes that alternatively spliced transcript variants encoding distinct isoforms have been identified. UniProt lists the protein as Cadherin-16 and places it in the cell membrane.
CDH16 has six extracellular cadherin domains, a transmembrane region and a truncated cytoplasmic domain, and lacks the prosequence and HAV adhesion recognition tripeptide typical of most classical cadherins. A mouse ortholog, Cdh16, exists; check the datasheet of any product for its validated reactivity.
Other cadherin superfamily members, including genes clustered with CDH16 on chromosome 16q22.1, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75309; product specifications from Assay Genie datasheets.