ELF3
ELF3 (E74 like ETS transcription factor 3, also known as EPR-1, ESE-1, ERT and ESX) is a member of the ETS transcription factor family. It binds ETS sequences in target promoters and activates transcription, with roles linked to epithelial cell differentiation and inflammation. Browse Assay Genie's current range of ELF3 research reagents below, or read on for the biology behind the target.
ELF3 is a transcriptional activator that binds and transactivates ETS sequences containing the consensus core GGA[AT]. It acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. It also transactivates the collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters, while it represses KRT4 promoter activity. NCBI Gene annotation describes sequence-specific double-stranded DNA binding and DNA-binding transcription activator activity specific to RNA polymerase II, with involvement in both positive and negative regulation of transcription.
The ELF3 protein is assigned to the ETS family and is found in the nucleus and cytoplasm; the NCBI Gene summary places it in the nucleoplasm. The ELF3 gene has mouse and rat orthologs, each named Elf3. Functional annotation points to a role in the inflammatory response, and ELF3 is described as involved in mediating vascular inflammation.
ELF3 may play an important role in epithelial cell differentiation and tumorigenesis, and may be a critical downstream effector of the ERBB2 signalling pathway. It may also be associated with mammary gland development and involution. In preimplantation embryos, ELF3 helps regulate transcription from TATA-less promoters, which is essential for preimplantation development. The earlier name, E74-like factor 3 (ets domain transcription factor, epithelial-specific), reflects its epithelial character, and the aliases EPR-1, ESE-1, ERT and ESX appear in the literature.
ELF3 may play an important role in epithelial cell differentiation and regulates promoters such as KRT8, FLG and TGM3.
ELF3 may contribute to tumorigenesis and may be a critical downstream effector of ERBB2 signalling.
ELF3 is involved in mediating vascular inflammation and transactivates inflammatory genes including CCL20, NOS2 and PTGS2.
ELF3 regulates transcription from TATA-less promoters in preimplantation embryos, which is essential for preimplantation development.
ELF3 is a transcriptional activator that binds ETS sequences containing a GGA[AT] core and transactivates target promoters. It cooperates with POU2F3 at SPRR2A and with RUNX1 at ANGPT1, represses the KRT4 promoter, and is linked to epithelial differentiation and vascular inflammation.
ELF3 stands for E74 like ETS transcription factor 3. Aliases include EPR-1, ESE-1, ERT and ESX, and the UniProt protein name is ETS-related transcription factor Elf-3. An earlier name was E74-like factor 3 (ets domain transcription factor, epithelial-specific).
Mouse and rat both have an Elf3 ortholog. ELF3 may play an important role in tumorigenesis, may act downstream of ERBB2 signalling, and is involved in mediating vascular inflammation. Check the datasheet of any product for its validated reactivity.
Other ETS family transcription factors and related regulators of epithelial and inflammatory gene expression.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78545; product specifications from Assay Genie datasheets.