CEMP1
CEMP1 (cementum protein 1, also known as cementoblastoma-derived protein 1 or CP-23) is a hydroxyapatite-binding protein linked to development of the periodontium. It is thought to promote cementoblast differentiation and cementum biomineralisation, and it also promotes cell proliferation. Browse Assay Genie's current range of CEMP1 research reagents below, or read on for the biology behind the target.
CEMP1 may play a role in development of the periodontium, the tissue that surrounds and supports the teeth. According to UniProt, it is proposed to promote the differentiation of multi-potent cells from the periodontal ligament into cementoblasts, the cells that form cementum. The protein binds hydroxyapatite and may promote biomineralisation of the cementum. It also promotes cell proliferation.
The human CEMP1 gene encodes cementum protein 1, listed in UniProt as cementoblastoma-derived protein 1. The protein is located in both the cytoplasm and the nucleus. NCBI Gene, drawing on the Alliance of Genome Resources, describes it as enabling hydroxyapatite binding activity and as being involved in biomineral tissue development, cell population proliferation and odontogenesis.
The alias CP-23 is also used for this target. Because its annotated roles centre on cementoblast differentiation, mineral binding and tooth development, CEMP1 is of interest to researchers studying how cementum and the supporting structures of the tooth are formed. Researchers working with the CEMP1 protein or CEMP1 gene should note that the functional annotation uses cautious wording ("may play a role"), so many aspects of its biology remain to be defined.
CEMP1 may contribute to development of the periodontium, the tissue that surrounds and supports the teeth.
CEMP1 may promote differentiation of multi-potent periodontal ligament cells into cementoblasts, which form cementum.
CEMP1 binds hydroxyapatite and may promote biomineralisation of the cementum, making it relevant to mineral tissue research.
CEMP1 is annotated as promoting cell proliferation, linking it to studies of cell population growth and odontogenesis.
CEMP1 may play a role in development of the periodontium by promoting differentiation of multi-potent periodontal ligament cells into cementoblasts, which form cementum. It binds hydroxyapatite, may promote cementum biomineralisation, and also promotes cell proliferation. Check the datasheet of any product for its validated reactivity.
The HGNC-approved name is cementum protein 1, and UniProt lists the protein as cementoblastoma-derived protein 1. The alias CP-23 is also recorded. The gene symbol is CEMP1, and the identifiers are HGNC:32553, NCBI Gene 752014 and UniProt Q6PRD7.
UniProt and NCBI Gene both place CEMP1 in the cytoplasm and the nucleus. NCBI Gene associates it with hydroxyapatite binding, biomineral tissue development, cell population proliferation and odontogenesis. The available data do not describe mouse or rat orthologs.
Other proteins involved in tooth development, biomineralisation and cell proliferation with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6PRD7; product specifications from Assay Genie datasheets.