NECTIN3
NECTIN3 (nectin-3, also known as PVRL3, PPR3, PVRR3, CD113 and CDw113) is a cell adhesion molecule of the nectin family. It promotes cell-cell adhesion through heterophilic trans-interactions and contributes to adherens junctions, synapses and ocular development. Browse Assay Genie's current range of NECTIN3 research reagents below, or read on for the biology behind the target.
NECTIN3 promotes cell-cell adhesion through heterophilic trans-interactions with nectin-like molecules or other nectins. One example is its trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Its trans-interaction with PVR induces activation of the small G proteins CDC42 and RAC through common signalling molecules such as SRC and RAP1. It also induces endocytosis-mediated down-regulation of PVR from the cell surface, which reduces cell movement and proliferation.
The protein takes part in forming cell-cell junctions, including adherens junctions and synapses, and is found at the cell membrane, the postsynaptic cell membrane and adherens junctions. It is involved in axon guidance by promoting contacts between commissural axons and floor plate cells. In the auditory epithelium, NECTIN1 in the membrane of hair cells associates with NECTIN3 on supporting cells. This heterotypic adhesion promotes the checkerboard-like pattern of the two cell types. NECTIN3 also plays a role in the morphology of the ciliary body.
The NECTIN3 gene encodes a member of the nectin family, which functions as adhesion molecules at adherens junctions. The protein interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in regulating directional motility, cell proliferation and survival. Mutations in the gene are believed to result in congenital ocular defects, and alternative splicing produces multiple transcript variants. The protein was formerly named poliovirus receptor-related 3 (PVRL3) and is classed as a CD molecule, CD113. The mouse ortholog is Nectin3.
NECTIN3 mediates heterophilic trans-interactions and helps form adherens junctions and synapses, making it a useful target for studying cell-cell contact.
NECTIN3 promotes contacts between commissural axons and floor plate cells, linking it to axon guidance and synapse formation.
Association of NECTIN3 on supporting cells with NECTIN1 on hair cells shapes the checkerboard-like pattern of the auditory epithelium.
NECTIN3 contributes to ciliary body morphology, and mutations in the gene are believed to cause congenital ocular defects.
NECTIN3 is a cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins and nectin-like proteins. It helps form adherens junctions and synapses, supports axon guidance, and its interaction with PVR activates CDC42 and RAC signalling and reduces cell movement and proliferation.
NECTIN3 is also called nectin-3, PVRL3, PPR3, PVRR3, DKFZP566B0846, CD113 and CDw113. The earlier name was poliovirus receptor-related 3. Alternative splicing of the gene gives rise to multiple transcript variants, so literature may refer to different forms.
NCBI Gene reports that mutations in NECTIN3 are believed to result in congenital ocular defects, in line with its role in ciliary body development. A mouse ortholog, Nectin3, exists. Check the datasheet of any product for its validated reactivity.
Other nectin family adhesion molecules and junction-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NQS3; product specifications from Assay Genie datasheets.