TALDO1
TALDO1 (transaldolase 1) is an enzyme of the non-oxidative pentose phosphate pathway that interconverts sugar phosphates. It is also reported to influence other metabolic pathways by shifting its location between the nucleus and the cytoplasm. Browse Assay Genie's current range of TALDO1 research reagents below, or read on for the biology behind the target.
TALDO1 catalyses the rate-limiting step of the non-oxidative phase of the pentose phosphate pathway. It carries out the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. Through this reaction the pathway links to the wider pool of sugar phosphates in the cell.
According to the NCBI Gene summary, transaldolase 1 provides ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. The pathway can also maintain glutathione in a reduced state, which helps protect sulfhydryl groups and cellular integrity from oxygen radicals. TALDO1 is not restricted to this role: by altering its subcellular localisation between the nucleus and the cytoplasm, it also affects other metabolite pathways.
The TALDO1 protein belongs to the transaldolase family, type 1 subfamily, and is found in both the nucleus and the cytoplasm. The functional TALDO1 gene lies on chromosome 11, while a pseudogene has been identified on chromosome 1, although map locations for it are conflicting. The second and third exons of the gene arose through insertion of a retrotransposable element. The gene is thought to be involved in multiple sclerosis. Orthologues are annotated in mouse and rat, both named Taldo1.
TALDO1 catalyses the rate-limiting step of the non-oxidative phase, making it a central enzyme for studying sugar phosphate interconversion.
The pathway supports NADPH supply and keeps glutathione reduced, protecting sulfhydryl groups and cells from oxygen radicals.
Transaldolase 1 supplies ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis.
The TALDO1 gene is thought to be involved in multiple sclerosis, prompting study of its role in disease.
TALDO1 catalyses the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. This is the rate-limiting step of the non-oxidative pentose phosphate pathway. It can also affect other metabolite pathways by moving between the nucleus and the cytoplasm.
Transaldolase is the UniProt protein name, transaldolase 1 is the HGNC full gene name, and TALDO1 is the approved gene symbol. No alternative aliases or previous symbols are listed. The enzyme carries EC number 2.2.1.2 and belongs to the type 1 subfamily of the transaldolase family.
Mouse and rat both have a Taldo1 orthologue. NCBI Gene notes that TALDO1 is thought to be involved in multiple sclerosis. A pseudogene is also reported on chromosome 1, though its map location is conflicting. Check the datasheet of any product for its validated reactivity.
Other pentose phosphate pathway enzymes and metabolic targets related to redox balance and nucleotide synthesis.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P37837; product specifications from Assay Genie datasheets.