TCFL5
TCFL5 (transcription factor like 5) is a putative nuclear transcription factor of the basic helix-loop-helix group, also known as Figlb, E2BP-1, CHA and bHLHe82. It is linked to transcriptional repression, control of cell proliferation and spermatogenesis. Browse Assay Genie's current range of TCFL5 research reagents below, or read on for the biology behind the target.
TCFL5 is annotated as a putative transcription factor. According to NCBI Gene, it enables DNA-binding transcription repressor activity specific to RNA polymerase II, as well as sequence-specific DNA binding to RNA polymerase II cis-regulatory regions. It is involved in the negative regulation of transcription by RNA polymerase II, which fits its role as a repressor that acts at regulatory DNA elements.
The TCFL5 protein is located in the nucleus, and NCBI Gene places it in the nucleoplasm. Beyond transcriptional control, the gene is linked to several processes, including regulation of cell population proliferation and spermatogenesis. UniProt notes that isoform 3 may play a role in early spermatogenesis, so isoform-specific work is relevant when studying germ cell biology.
HGNC classifies the TCFL5 gene within the basic helix-loop-helix proteins, and the symbol is also written bHLHe82 in that nomenclature. Earlier names include transcription factor-like 5 (basic helix-loop-helix), and the aliases Figlb, E2BP-1 and CHA appear in the literature. Researchers studying transcriptional repression, proliferation control or male germline development may encounter TCFL5 under any of these names.
TCFL5 shows DNA-binding repressor activity at RNA polymerase II cis-regulatory regions, making it relevant to studies of negative gene regulation.
TCFL5 is involved in spermatogenesis, and isoform 3 may act in early spermatogenesis, so it is a candidate for germ cell studies.
NCBI Gene links TCFL5 to regulation of cell population proliferation, supporting its use in growth-control research.
As a member of the basic helix-loop-helix proteins, TCFL5 helps in comparative studies of this transcription factor group.
TCFL5 is a putative transcription factor. NCBI Gene describes DNA-binding transcription repressor activity at RNA polymerase II cis-regulatory regions, and involvement in negative regulation of transcription, regulation of cell population proliferation and spermatogenesis. The protein is found in the nucleus.
TCFL5 is also called Figlb, E2BP-1, CHA and bHLHe82, and was previously named transcription factor-like 5 (basic helix-loop-helix). UniProt notes that isoform 3 may play a role in early spermatogenesis, so check which isoform a study addresses.
Yes. HGNC places the TCFL5 gene in the basic helix-loop-helix proteins group. Orthologue details are not given in the source data here, so check the datasheet of any product for its validated reactivity.
Other basic helix-loop-helix transcription factors and regulators of gene expression with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UL49; product specifications from Assay Genie datasheets.