IFI44
IFI44 (interferon induced protein 44) is a cytoplasmic protein of the IFI44 family that aggregates to form microtubular structures. It is also known as MTAP44, p44 and TLDC5, and is predicted to take part in the immune response. Browse Assay Genie's current range of IFI44 research reagents below, or read on for the biology behind the target.
The annotated function of IFI44 is structural: the protein aggregates to form microtubular structures. UniProt records its subcellular location as the cytoplasm, and NCBI Gene likewise describes it as predicted to be located in the cytosol. Beyond this, the detailed molecular mechanism of the IFI44 protein is not defined in the sources used here.
NCBI Gene summarises IFI44 as predicted to be involved in the immune response, and as predicted to act upstream of or within the cellular response to virus and the response to bacterium. These are predictions provided by the Alliance of Genome Resources rather than established mechanisms, so they are best treated as a starting point for experimental work on how the IFI44 gene contributes to host defence.
The official HGNC name is interferon induced protein 44, and the protein is listed in UniProt as interferon-induced protein 44. Aliases and previous symbols include MTAP44, p44 and TLDC5. The last of these reflects its place in the HGNC gene group of TLDc domain containing proteins. UniProt places the protein in the IFI44 family, and a mouse ortholog, Ifi44, is recorded for the gene.
IFI44 is predicted to be involved in the immune response, making it a candidate for studies of interferon-linked host defence.
The gene is predicted to act upstream of or within the cellular response to virus, relevant to infection models.
IFI44 is predicted to function in the response to bacterium, which supports work on host responses to bacterial challenge.
The protein aggregates to form microtubular structures, an area for investigating its cytoplasmic organisation and role.
UniProt annotates IFI44 as a protein that aggregates to form microtubular structures. NCBI Gene adds that it is predicted to be involved in the immune response, including the cellular response to virus and the response to bacterium. It is located in the cytoplasm.
IFI44 is the HGNC symbol for interferon induced protein 44. Aliases and previous symbols include MTAP44, p44 and TLDC5. UniProt lists the protein name as interferon-induced protein 44 and assigns it to the IFI44 family.
A mouse ortholog, Ifi44, is recorded for the human gene. A rat ortholog is not given in the data used here. Check the datasheet of any product for its validated reactivity.
Other interferon-induced proteins and innate immune response targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TCB0; product specifications from Assay Genie datasheets.