ANXA11
ANXA11 (annexin A11, also known as ANX11) is a member of the annexin family of calcium-dependent phospholipid-binding proteins. It binds calcyclin in a calcium-dependent manner and is required for midbody formation and completion of cytokinesis. Browse Assay Genie's current range of ANXA11 research reagents below, or read on for the biology behind the target.
ANXA11 belongs to the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins share a common architecture: a unique N-terminal domain and conserved C-terminal domains that contain the calcium-dependent phospholipid-binding sites. Functionally, annexin A11 binds specifically to calcyclin in a calcium-dependent manner, and it is required for midbody formation and for completion of the terminal phase of cytokinesis.
The ANXA11 gene encodes the annexin A11 protein, which UniProt records in several compartments: the cytoplasm, the nucleoplasm and nuclear envelope, the cytoskeleton at the spindle, and the melanosome. The spindle localisation fits with its role in cell division. NCBI Gene reports that several transcript variants encode two different isoforms. HGNC places the gene in the annexin gene group, and a mouse ortholog, Anxa11, is annotated.
The protein was first noted as a 56-kD antigen recognised by sera from patients with various autoimmune diseases, which is why it appears in the autoimmunity literature as well as in work on calcium signalling and cell division. Researchers studying ANXA11 often compare it with other annexin family members, since the conserved C-terminal domains are shared while the N-terminal domains differ. Because the N-terminal region is unique to each annexin, it is a useful distinguishing feature when designing an ANXA11 antibody or ANXA11 ELISA kit experiment.
ANXA11 is required for midbody formation and completion of the terminal phase of cytokinesis, making it relevant to studies of cell division.
ANXA11 binds calcyclin in a calcium-dependent manner and carries calcium-dependent phospholipid-binding sites, linking it to calcium-regulated interactions.
The protein is a 56-kD antigen recognised by sera from patients with various autoimmune diseases, supporting its use in autoantigen research.
Unique N-terminal domains and conserved C-terminal domains make ANXA11 a useful point of comparison across the annexin family.
ANXA11 is a calcium-dependent phospholipid-binding protein of the annexin family. It binds specifically to calcyclin in a calcium-dependent manner and is required for midbody formation and completion of the terminal phase of cytokinesis. UniProt places it at the spindle, among other locations.
ANXA11 is the approved HGNC symbol for annexin A11, with ANX11 listed as an alias. NCBI Gene reports several transcript variants that encode two different isoforms. The protein is also described as a 56-kD autoantigen in the literature.
A mouse ortholog, Anxa11, is annotated. In terms of disease relevance, the source data describe the protein as an antigen recognised by sera from patients with various autoimmune diseases. Check the datasheet of any product for its validated reactivity.
Other annexin family members that bind phospholipids in a calcium-dependent manner, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50995; product specifications from Assay Genie datasheets.