SDC3
SDC3 (syndecan 3, also known as N-syndecan or SYND3) is a cell surface proteoglycan of the syndecan family that may bear heparan sulfate. It is proposed to influence cell shape by acting on the actin cytoskeleton. Browse Assay Genie's current range of SDC3 research reagents below, or read on for the biology behind the target.
SDC3 is a cell surface proteoglycan that may bear heparan sulfate chains. According to UniProt and RefSeq annotation, it may have a role in the organisation of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. In other words, the protein is thought to link the extracellular environment, through its sugar modifications, to the cytoskeletal machinery inside the cell. These functions are described as possible rather than established, so the SDC3 protein remains an open subject for mechanistic work.
The SDC3 gene encodes a protein that belongs to the syndecan proteoglycan family, which is listed by HGNC as the Syndecans gene group. UniProt records its subcellular location as the cell membrane, consistent with its role as a cell surface molecule. Other members of the family include SDC2 and SDC4, which are useful comparators when studying how individual syndecans differ in function.
SDC3 was previously named syndecan 3 (N-syndecan), and N-syndecan and SYND3 remain in use as aliases. Mouse and rat both carry an Sdc3 ortholog, which allows the protein to be studied in common model systems. NCBI Gene notes that allelic variants of this gene have been associated with obesity, giving the gene relevance to metabolic research as well as to cell biology.
SDC3 may organise cell shape by affecting the actin cytoskeleton, making it a candidate for studies of surface-to-cytoskeleton signalling.
As a cell surface proteoglycan that may bear heparan sulfate, SDC3 is relevant to work on sugar-dependent signalling at the membrane.
Allelic variants of the SDC3 gene have been associated with obesity, prompting its study in metabolic and genetic research.
SDC3 belongs to the syndecan family, so it is often examined alongside SDC2 and SDC4 to compare family member roles.
SDC3 is a cell surface proteoglycan that may bear heparan sulfate. It may help organise cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. These roles are described as possible in UniProt and NCBI Gene.
SDC3 is the HGNC symbol for syndecan 3. It is also called N-syndecan and SYND3, and its previous HGNC name was syndecan 3 (N-syndecan). UniProt lists the protein as Syndecan-3, and HGNC places it in the Syndecans gene group.
Mouse and rat both have an Sdc3 ortholog, so the protein can be studied in these models; check the datasheet of any product for its validated reactivity. NCBI Gene reports that allelic variants of SDC3 have been associated with obesity.
Other syndecan family members and syndecan-binding proteins relevant to cell surface proteoglycan research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75056; product specifications from Assay Genie datasheets.