AMIGO1
AMIGO1 (adhesion molecule with Ig like domain 1, also known as amphoterin-induced protein 1, AMIGO or KIAA1163) is a cell-surface member of the immunoglobulin superfamily. It promotes neurite growth and fasciculation and modulates the voltage-gated potassium channel KCNB1. Browse Assay Genie's current range of AMIGO1 research reagents below, or read on for the biology behind the target.
AMIGO1 promotes the growth and fasciculation of neurites from cultured hippocampal neurons. It may also contribute to fasciculation and myelination of developing neural axons, and it may have a role in regeneration and neural plasticity in the adult nervous system. The protein may mediate both homophilic and heterophilic cell-cell interaction, and it may contribute to signal transduction through its intracellular domain.
A second function concerns ion channels. When assembled with KCNB1, AMIGO1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel. Consistent with this, NCBI Gene summary annotations predict that the gene enables potassium channel regulator activity and that the protein is found in the voltage-gated potassium channel complex, as well as in dendrites and the neuronal cell body membrane.
The AMIGO1 gene encodes a member of the immunoglobulin superfamily and the AMIGO family, classed by HGNC among V-set domain containing proteins. UniProt records its locations as the cell membrane, perikaryon, dendrites and axons. Predicted biological processes include heterophilic cell-cell adhesion, nervous system development and positive regulation of nervous system development. AMIGO2 is another member of the AMIGO family. Mouse and rat both carry an Amigo1 ortholog, so the protein can be studied in common rodent models.
AMIGO1 promotes neurite growth and fasciculation in cultured hippocampal neurons, making it a useful target for studying how axons bundle during development.
AMIGO1 may be involved in fasciculation and myelination of developing neural axons, which makes it relevant to studies of axonal maturation.
AMIGO1 may have a role in regeneration and neural plasticity in the adult nervous system, a focus for research on neuronal repair.
Assembled with KCNB1, AMIGO1 modulates the gating of the delayed rectifier voltage-dependent potassium channel, linking adhesion biology to neuronal excitability.
AMIGO1 promotes growth and fasciculation of neurites from cultured hippocampal neurons and may contribute to axon myelination, regeneration and neural plasticity. It may mediate homophilic and heterophilic cell-cell interaction, and with KCNB1 it modulates potassium channel gating. Check the datasheet of any product for its validated reactivity.
The HGNC name is adhesion molecule with Ig like domain 1, and UniProt lists amphoterin-induced protein 1. Aliases and previous symbols include AMIGO and KIAA1163. The AMIGO1 gene symbol is the same in human, mouse (Amigo1) and rat (Amigo1).
AMIGO1 belongs to the immunoglobulin superfamily and the AMIGO family. HGNC places it in the V-set domain containing group and the adhesion molecule with Ig like domain family, which also includes AMIGO2. Mouse and rat Amigo1 are orthologs of the human gene.
Other AMIGO family members and related adhesion molecules with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86WK6; product specifications from Assay Genie datasheets.