TBX18
TBX18 (T-box transcription factor 18, previously T-box 18) is a nuclear transcriptional repressor of the T-box family. It contributes to the embryonic development of several tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Browse Assay Genie's current range of TBX18 research reagents below, or read on for the biology behind the target.
TBX18 acts as a transcriptional repressor that is involved in developmental processes in a variety of tissues and organs. The annotated roles include development of the heart and coronary vessels, the ureter and the vertebral column, and the protein is required for embryonic development of the sino atrial node (SAN) head area. According to the RefSeq summary, it represses transcription by antagonising transcriptional activators in the T-box family.
The TBX18 gene encodes a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is defined by the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation within this domain. The TBX18 protein belongs to the vertebrate-specific Tbx1 sub-family. It is localised to the nucleus, in keeping with its role in regulating gene expression. The protein forms homo- or heterodimers with other T-box transcription factors or with other transcription factors, which is relevant when studying how T-box proteins cooperate or compete at target genes.
HGNC classifies the gene in the T-box transcription factors group, and its previous name was T-box 18. The mouse ortholog is Tbx18, which is commonly used in developmental studies. Because TBX18 is a transcription factor with a developmental role, it is typically studied in the context of organ formation, lineage specification and the regulatory networks shared with other T-box family members such as TBX1 and TBX15.
TBX18 is involved in development of the heart and coronary vessels and is required for embryonic development of the sino atrial node head area.
The protein participates in developmental processes of the ureter, making it a subject in studies of urinary tract formation.
TBX18 contributes to development of the vertebral column, linking this T-box factor to embryonic axial skeleton formation.
As a repressor that antagonises T-box activators and forms homo- or heterodimers, TBX18 is used to study T-box protein interplay.
TBX18 is a transcriptional repressor involved in the development of several tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. It is required for embryonic development of the sino atrial node head area, and it antagonises transcriptional activators in the T-box family.
The HGNC full name is T-box transcription factor 18, and the previous name was T-box 18. No other aliases are listed. TBX18 belongs to the T-box transcription factors and, within them, to the vertebrate-specific Tbx1 sub-family.
TBX18 belongs to an evolutionarily conserved family of T-box transcription factors that act in embryonic development. The mouse ortholog is Tbx18. Check the datasheet of any product for its validated reactivity before choosing reagents for a particular species.
Other T-box transcription factors involved in development and gene regulation, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95935; product specifications from Assay Genie datasheets.