CCNB2
CCNB2 (cyclin B2, also known as HsT17299) is a B-type cyclin of the cyclin family and is essential for control of the cell cycle at the G2/M transition. It associates with p34cdc2 as part of the cell cycle regulatory machinery. Browse Assay Genie's current range of CCNB2 research reagents below, or read on for the biology behind the target.
CCNB2 encodes cyclin B2, a protein that is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is one of the two B-type cyclins, B1 and B2, which associate with p34cdc2 and form essential components of the cell cycle regulatory machinery. Researchers studying mitotic entry therefore often examine cyclin B2 alongside its partner kinase and its paralogue CCNB1.
Cyclin B2 belongs to the cyclin family and, within it, the cyclin AB subfamily. The two B-type cyclins differ in subcellular localisation: cyclin B1 co-localises with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. This distinction suggests the two proteins act at different sites within the cell, even though both partner with p34cdc2. The HGNC places the CCNB2 gene in the groups of cyclins and centriolar satellite proteins. The UniProt entry is G2/mitotic-specific cyclin-B2, and the mouse ortholog is Ccnb2.
Cyclin B2 also binds transforming growth factor beta RII. On this basis, the cyclin B2/cdc2 complex may play a key role in transforming growth factor beta-mediated cell cycle control, linking growth factor signalling to the machinery that governs mitosis. Reagents for the CCNB2 gene product, including any CCNB2 antibody or CCNB2 ELISA kit, are used to study these roles in cell cycle regulation.
Cyclin B2 is essential for control of the cell cycle at the G2/M transition, making it a key subject in studies of mitotic entry.
B-type cyclins associate with p34cdc2 as core components of cell cycle regulatory machinery, so cyclin B2 is relevant to cyclin-dependent kinase studies.
Cyclin B2 is primarily associated with the Golgi region, unlike microtubule-associated cyclin B1, allowing comparison of B-type cyclin localisation.
Cyclin B2 binds transforming growth factor beta RII, and cyclin B2/cdc2 may contribute to TGF-beta-mediated cell cycle control.
CCNB2 encodes cyclin B2, which is essential for control of the cell cycle at the G2/M (mitosis) transition. Like cyclin B1, it associates with p34cdc2 as part of the cell cycle regulatory machinery, and it is primarily associated with the Golgi region.
The HGNC gene symbol is CCNB2 and the approved name is cyclin B2. The alias HsT17299 is also listed, and UniProt names the protein G2/mitotic-specific cyclin-B2. It belongs to the cyclin family, cyclin AB subfamily, alongside B-type cyclin CCNB1.
Both associate with p34cdc2, but cyclin B1 co-localises with microtubules while cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds transforming growth factor beta RII. A mouse ortholog, Ccnb2, exists; check the datasheet of any product for its validated reactivity.
Other B-type cyclins and cell cycle regulators with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95067; product specifications from Assay Genie datasheets.