DTNB
DTNB (dystrobrevin beta) is a scaffolding protein of the dystrophin family and a component of the dystrophin-associated protein complex. It assembles DMD and SNTA1 at the basal membrane of kidney cells and liver sinusoids. Browse Assay Genie's current range of DTNB research reagents below, or read on for the biology behind the target.
DTNB is a scaffolding protein that assembles DMD and SNTA1 molecules at the basal membrane of kidney cells and liver sinusoids. It is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. Dystrobrevin beta is thought to interact with syntrophin and with DP71, the short form of dystrophin.
The DTNB gene encodes dystrobrevin beta, which belongs to the dystrobrevin subfamily of the dystrophin family. HGNC classifies it in the ZZ-type zinc finger gene group, and it was previously named "dystrobrevin, beta". UniProt records its localisation to the cytoplasm, postsynaptic density, dendrites, basal cell membrane, postsynapse and nucleus. Mouse and rat both carry a Dtnb ortholog, so DTNB can be studied in common rodent models.
Beyond its structural role, DTNB may act as a repressor of the SYN1 promoter by binding repressor element-1 (RE-1). Through this it may regulate SYN1 expression and may contribute to the control of cell proliferation during the early phase of neural differentiation. It may also be required for the proper maturation and function of a subset of inhibitory synapses. The DPC localises to the sarcolemma, and its disruption is associated with various forms of muscular dystrophy, which places DTNB in a pathway of wide interest for neuromuscular research.
DTNB is a component of the DPC, whose disruption is associated with various forms of muscular dystrophy.
DTNB assembles DMD and SNTA1 at the basal membrane of kidney cells and liver sinusoids.
DTNB may be required for the maturation and function of a subset of inhibitory synapses.
DTNB may repress the SYN1 promoter via RE-1 and may help regulate proliferation early in neural differentiation.
DTNB is a scaffolding protein that assembles DMD and SNTA1 at the basal membrane of kidney cells and liver sinusoids. It may also repress the SYN1 promoter through RE-1 binding and may be needed for the maturation and function of some inhibitory synapses.
DTNB stands for dystrobrevin beta, and the previous HGNC name was "dystrobrevin, beta". No other aliases or previous symbols are listed. It is distinct from dystrobrevin alpha, which is a separate DPC component, and from DTNBP1, a different gene.
DTNB is part of the dystrophin-associated protein complex, whose disruption is associated with various forms of muscular dystrophy. Mouse and rat each have a Dtnb ortholog; check the datasheet of any product for its validated reactivity.
Related targets that sit alongside DTNB in the research literature, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60941; product specifications from Assay Genie datasheets.