CRADD
CRADD (CARD and death domain containing adaptor protein, also known as RAIDD) is a death domain-containing adaptor that links caspase-2 to upstream signalling complexes. It promotes apoptosis as a core component of the PIDDosome. Browse Assay Genie's current range of CRADD research reagents below, or read on for the biology behind the target.
CRADD is an adaptor protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates caspase-2 and triggers apoptosis. It also recruits caspase-2 to the TNFR-1 signalling complex through its interactions with RIPK1 and TRADD, and may play a role in the tumour necrosis factor-mediated signalling pathway. In this way CRADD acts as a bridge between death-signalling platforms and the caspase that executes the response.
The CRADD gene encodes a protein containing a death domain (DD) motif. According to the NCBI Gene summary, the protein recruits caspase-2 (ICH1) to the cell death signal transduction complex, which includes TNFR1A and RIPK1 (RIP kinase), and acts in promoting apoptosis. UniProt records the CRADD protein in the cytoplasm and the nucleus. The mouse ortholog is named Cradd. Alternative splicing results in multiple transcript variants, and a related pseudogene is found on chromosome 3.
HGNC places the gene in the caspase recruitment domain containing group and in the caspase-2 PIDDosome complex group. Its previous name was CASP2 and RIPK1 domain containing adaptor with death domain, and RAIDD remains a widely used alias. A mutation in this gene has been associated with cognitive disability, which makes CRADD of interest beyond cell death research.
CRADD promotes apoptosis by bringing caspase-2 into cell death signal transduction complexes, making it a useful node for studying caspase activation.
CRADD associates with PIDD1 and caspase-2 to form the PIDDosome, a complex that activates caspase-2 and triggers apoptosis.
CRADD recruits caspase-2 to the TNFR-1 complex through RIPK1 and TRADD, and may contribute to tumour necrosis factor-mediated signalling.
A mutation in the CRADD gene has been associated with cognitive disability, linking this adaptor to studies of cognitive function.
CRADD is an adaptor protein that associates with PIDD1 and caspase-2 to form the PIDDosome, which activates caspase-2 and triggers apoptosis. It also recruits caspase-2 to the TNFR-1 signalling complex through RIPK1 and TRADD, and may contribute to tumour necrosis factor-mediated signalling.
Yes. RAIDD is an alias for CRADD. The gene's previous HGNC name was CASP2 and RIPK1 domain containing adaptor with death domain, which describes its role linking caspase-2 and RIPK1. The current name refers to its CARD and death domain features. Transcript variants arise by alternative splicing.
A mouse ortholog, Cradd, is recorded for this gene. NCBI Gene reports that a mutation in CRADD was associated with cognitive disability, and that a related pseudogene lies on chromosome 3. Check the datasheet of any product for its validated reactivity.
Caspase-2, PIDDosome partners and TNFR-1 complex proteins involved in apoptosis signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P78560; product specifications from Assay Genie datasheets.