CLASP1
CLASP1 (cytoplasmic linker associated protein 1, CLIP-associating protein 1) is a non-motor microtubule plus-end tracking protein that stabilises dynamic microtubules. It is also known as KIAA0622 and MAST1, and belongs to the CLASP family. Browse Assay Genie's current range of CLASP1 research reagents below, or read on for the biology behind the target.
CLASP1 is a microtubule plus-end tracking protein that promotes the stabilisation of dynamic microtubules. It is a non-motor microtubule-associated protein that interacts with CLIPs such as CLIP170. CLASP1 is involved in the nucleation of non-centrosomal microtubules that originate from the trans-Golgi network, and it is required for polarising cytoplasmic microtubule arrays towards the leading edge of migrating cells.
At the cell cortex, CLASP1 may increase the frequency of rescue of depolymerising microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical stabilising activity is regulated at least in part by phosphatidylinositol 3-kinase signalling. CLASP1 performs a similar stabilising function at the kinetochore, which is essential for the bipolar alignment of chromosomes on the mitotic spindle. The NCBI Gene summary describes its role in regulating microtubule dynamics at the kinetochore and throughout the spindle.
The CLASP1 gene encodes CLIP-associating protein 1, a member of the CLASP family and of the HGNC TOG domain containing gene group. UniProt records its localisation to the cytoskeleton, centrosome, kinetochore, spindle and trans-Golgi network. The gene has also been listed under the names KIAA0622 and MAST1. The mouse ortholog is Clasp1. Researchers studying CLASP1 protein typically do so in the contexts of cell division, cell migration and Golgi-derived microtubule organisation.
CLASP1 stabilises dynamic microtubules and promotes rescue of depolymerising plus-ends, making it a key protein for studying microtubule behaviour.
CLASP1 acts at the kinetochore and spindle and is essential for bipolar alignment of chromosomes on the mitotic spindle.
CLASP1 is required for polarising cytoplasmic microtubule arrays towards the leading edge of migrating cells.
CLASP1 is involved in nucleating non-centrosomal microtubules from the trans-Golgi network, linking Golgi organisation to the cytoskeleton.
CLASP1 is a microtubule plus-end tracking protein that stabilises dynamic microtubules. It contributes to non-centrosomal microtubule nucleation at the trans-Golgi network, microtubule polarisation in migrating cells, cortical rescue of depolymerising microtubules and chromosome alignment at the kinetochore during mitosis.
The official full name is cytoplasmic linker associated protein 1, and UniProt calls the protein CLIP-associating protein 1. Aliases and previous symbols include KIAA0622 and MAST1. It belongs to the CLASP family and the TOG domain containing gene group.
The mouse has an ortholog named Clasp1, so the protein can be studied in mouse models. No rat ortholog is given in the data supplied here. Check the datasheet of any product for its validated reactivity.
Other CLASP family members, CLIP proteins and cortical microtubule-anchoring partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7Z460; product specifications from Assay Genie datasheets.