CALML5
CALML5 (calmodulin like 5, also known as CLSP) is a calcium-binding protein of the epidermis, related to the calmodulin family. It is linked to the terminal differentiation of keratinocytes. Browse Assay Genie's current range of CALML5 research reagents below, or read on for the biology behind the target.
CALML5 is a calcium-binding protein. Functional studies with recombinant protein show that it binds calcium and undergoes a conformational change when it does so, a behaviour characteristic of calmodulin-related proteins. UniProt annotates it as possibly involved in the terminal differentiation of keratinocytes.
The CALML5 gene encodes a calcium-binding protein expressed in the epidermis and related to the calmodulin family. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. The protein can also associate with transglutaminase 3, which has been shown to be a key enzyme in the terminal differentiation of keratinocytes. This association places CALML5 close to the machinery that completes keratinocyte maturation. HGNC classifies the gene in the EF-hand domain containing group.
The protein is listed in UniProt as calmodulin-like protein 5, and the gene was previously named calmodulin-like 5, with the alias CLSP. Researchers studying the CALML5 gene or the CALML5 protein typically do so in the context of epidermal biology, calcium signalling and keratinocyte differentiation.
CALML5 expression is restricted to differentiating keratinocytes and the protein may contribute to their terminal differentiation.
CALML5 is a calcium-binding protein expressed in the epidermis, making it a relevant marker in studies of epidermal tissue.
Recombinant CALML5 binds calcium and changes conformation, offering a model for studying calmodulin-related EF-hand proteins.
CALML5 can associate with transglutaminase 3, a key enzyme in keratinocyte terminal differentiation, supporting studies of this protein partnership.
CALML5 binds calcium and undergoes a conformational change when it does so. UniProt notes it may be involved in the terminal differentiation of keratinocytes, and it can associate with transglutaminase 3, an enzyme important in that process.
The HGNC full name is calmodulin like 5, and the previous name was calmodulin-like 5. The alias is CLSP. UniProt lists the protein as calmodulin-like protein 5. These names all refer to the same gene and protein.
According to the NCBI Gene summary, CALML5 is expressed in the epidermis, with abundant expression detected only in reconstructed epidermis and restricted to differentiating keratinocytes. Orthologue information is not given in the source data, so check the datasheet of any product for its validated reactivity.
Other calmodulin-like and EF-hand calcium-binding proteins relevant to epidermal biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NZT1; product specifications from Assay Genie datasheets.