ENTR1
ENTR1 (endosome associated trafficking regulator 1, also known as SDCCAG3 and NY-CO-3) is an endosome-associated protein that contributes to membrane receptor sorting, cytokinesis and ciliogenesis. It belongs to the ENTR1 family. Browse Assay Genie's current range of ENTR1 research reagents below, or read on for the biology behind the target.
ENTR1 is an endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. It is involved in the trafficking of cargo from the endosome back to the plasma membrane, and in the recycling of SNX27-retromer-dependent cargo proteins such as GLUT1. NCBI Gene annotation likewise places the protein in endocytic recycling and in the retromer complex.
The ENTR1 protein also contributes to cilium biology. It plays a role in the formation of cilia, is described as a positive regulator of cilium assembly and of protein localisation to the cilium, and is involved in the localisation of cargo proteins such as PKD2 at primary cilia. In cytokinesis, its function may involve PTPN13 and GIT1. ENTR1 is further involved in presenting the tumour necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and so in modulating TNF-induced apoptosis.
UniProt records the protein in the cytoplasm, early and recycling endosomes, the midbody, the centrosome as part of the microtubule organising centre, and the basal body of the cilium. The ENTR1 gene was previously named serologically defined colon cancer antigen 3, and the symbols SDCCAG3 and NY-CO-3 are still used in the literature. The mouse ortholog is Entr1.
ENTR1 is involved in endosome-to-plasma membrane recycling of SNX27-retromer-dependent cargo such as GLUT1, making it relevant to receptor sorting research.
ENTR1 plays a role in cilium formation and in the localisation of cargo such as PKD2 at primary cilia.
ENTR1 is involved in regulating cytokinesis, a function that may involve PTPN13 and GIT1, and it is found at the midbody.
ENTR1 influences cell-surface presentation of TNFRSF1A, and hence the modulation of TNF-induced apoptosis.
ENTR1 is an endosome-associated protein involved in membrane receptor sorting, cytokinesis and ciliogenesis. It supports recycling of SNX27-retromer-dependent cargo such as GLUT1 to the plasma membrane, helps localise PKD2 at primary cilia, and affects TNFRSF1A presentation at the cell surface.
The HGNC name is endosome associated trafficking regulator 1. Aliases include SDCCAG3 and NY-CO-3, and the previous gene name was serologically defined colon cancer antigen 3. UniProt lists the protein as Endosome-associated-trafficking regulator 1, a member of the ENTR1 family.
The data identify a mouse ortholog, Entr1, so the gene is conserved at least in mammals. No rat ortholog is given in the source data. Researchers should check the datasheet of any product for its validated reactivity.
Retromer cargo, ciliary proteins, cytokinesis-linked partners and TNF pathway components related to ENTR1 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96C92; product specifications from Assay Genie datasheets.